The development of effective treatments for opioid dependence is of great importance given the devastating consequences of the disease. Pharmacotherapies for opioid addiction include opioid agonists, partial agonists, opioid antagonists, and alpha-2-adrenergic agonists, which are targeted toward either detoxification or long-term agonist maintenance. Agonist maintenance therapy is currently the recommended treatment for opioid dependence due to its superior outcomes relative to detoxification. Detoxification protocols have limited long-term efficacy, and patient discomfort remains a significant therapy challenge. Buprenorphine's effectiveness relative to methadone remains a controversy and may be most appropriate for patients in need of low doses of agonist treatment. Buprenorphine appears superior to alpha-2 agonists, however, and office-based treatment with buprenorphine in the USA is gaining support. Studies of sustained-release formulations of naltrexone suggest improved effectiveness for retention and sustained abstinence; however, randomized clinical trials are needed.
Double-blind comparison of methadone and placebo maintenance treatments of narcotic addicts in Hong Kong
Efficacy of clonidine, guanfacine and methadone in the rapid detoxification of heroin addicts: a controlled clinical trial
The hypothalamic-pituitary-luteal axis in women: effects of long-term orally active opioid antagonist (naltrexone) administration
The safety profile of naltrexone in the treatment of alcoholism. Results from a multicenter usage study. The Naltrexone Usage Study Group
A preliminary investigation of the management of alcohol dependence with naltrexone by primary care providers
Accelerated lofexidine treatment regimen compared with conventional lofexidine and methadone treatment for in-patient opiate detoxification
A randomized trial of buprenorphine maintenance for heroin dependence in a primary care clinic for substance users versus a methadone clinic
Differences between general practitioner- and addiction centre-prescribed buprenorphine substitution therapy in France. Preliminary results
Buprenorphine and naloxone combinations: the effects of three dose ratios in morphine-stabilized, opiate-dependent volunteers
Efficacy of daily and alternate-day dosing regimens with the combination buprenorphine-naloxone tablet
Safety, efficacy, and long-term results of a modified version of rapid opiate detoxification under general anaesthesia: a prospective study in methadone, heroin, codeine and morphine addicts
Ultra rapid opiate detoxification as compared to 30-day inpatient detoxification program--a retrospective follow-up study
Buprenorphine and naloxone co-administration in opiate-dependent patients stabilized on sublingual buprenorphine
Thrice-weekly supervised dosing with the combination buprenorphine-naloxone tablet is preferred to daily supervised dosing by opioid-dependent humans
Examining the limits of the buprenorphine interdosing interval: daily, every-third-day and every-fifth-day dosing regimens
Two methods of community detoxification from opiates: an open-label comparison of lofexidine and buprenorphine
A death following ultra-rapid opiate detoxification: the General Medical Council adjudicates on a commercialized detoxification
A placebo-controlled study of high dose buprenorphine in opiate dependents waiting for medication-assisted rehabilitation in Oslo, Norway
Detoxification of opiate addicts with multiple drug abuse: a comparison of buprenorphine vs. methadone
A randomized controlled trial of buprenorphine in the management of short-term ambulatory heroin withdrawal
1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial
Opioid detoxification with buprenorphine, clonidine, or methadone in hospitalized heroin-dependent patients with HIV infection
Buprenorphine versus methadone maintenance therapy: a randomized double-blind trial with 405 opioid-dependent patients
Cessation of methadone maintenance treatment using buprenorphine: transfer from methadone to buprenorphine and subsequent buprenorphine reductions
Naltrexone implants can completely prevent early (1-month) relapse after opiate detoxification: a pilot study of two cohorts totalling 101 patients with a note on naltrexone blood levels
Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone
Evaluation of buprenorphine maintenance treatment in a French cohort of HIV-infected injecting drug users
Naltrexone: report of lack of hepatotoxicity in acute viral hepatitis, with a review of the literature
Naltrexone depot for treatment of alcohol dependence: a multicenter, randomized, placebo-controlled clinical trial
Efficacy and tolerability of long-acting injectable naltrexone for alcohol dependence: a randomized controlled trial
A multi-center randomized trial of buprenorphine-naloxone versus clonidine for opioid detoxification: findings from the National Institute on Drug Abuse Clinical Trials Network
Anesthesia-assisted vs buprenorphine- or clonidine-assisted heroin detoxification and naltrexone induction: a randomized trial
A comparison of buprenorphine and lofexidine for community opiate detoxification: results from a randomized controlled trial
Injectable, sustained-release naltrexone for the treatment of opioid dependence: a randomized, placebo-controlled trial
Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors
Methadone and buprenorphine for the management of opioid dependence: a systematic review and economic evaluation
Syncope and QT prolongation among patients treated with methadone for heroin dependence in the city of Copenhagen
A stepped care strategy using buprenorphine and methadone versus conventional methadone maintenance in heroin dependence: a randomized controlled trial
Levo-alpha-acetylmethadol (LAAM) versus methadone maintenance: 1-year treatment retention, outcomes and status
Risk of fatal overdose during and after specialist drug treatment: the VEdeTTE study, a national multi-site prospective cohort study
Comparing drug-related hospital morbidity following heroin dependence treatment with methadone maintenance or naltrexone implantation
A Phase 3 placebo-controlled, double-blind, multi-site trial of the alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal
Extended vs short-term buprenorphine-naloxone for treatment of opioid-addicted youth: a randomized trial
Effects of prototypic calcium channel blockers in methadone-maintained humans responding under a naloxone discrimination procedure
Design, synthesis, and biological evaluation of 14-heteroaromatic-substituted naltrexone derivatives: pharmacological profile switch from mu opioid receptor selectivity to mu/kappa opioid receptor dual selectivity
Tramadol versus methadone for treatment of opiate withdrawal: a double-blind, randomized, clinical trial
Statement of the American Society Of Addiction Medicine Consensus Panel on the use of buprenorphine in office-based treatment of opioid addiction
An oxycodone conjugate vaccine elicits drug-specific antibodies that reduce oxycodone distribution to brain and hot-plate analgesia
Evaluation of buprenorphine dosage adequacy in opioid receptor agonist substitution therapy for heroin dependence: first use of the BUprenorphine-naloxone Dosage Adequacy eVAluation (BUDAVA) questionnaire
Pharmacokinetics of a new immediate-release methadone tablet formulation with decreased in vitro solubility
The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence
The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of substance use and related disorders. Part 2: Opioid dependence
Opium tincture versus methadone syrup in management of acute raw opium withdrawal: A randomized, double-blind, controlled trial
Opioid withdrawal, craving, and use during and after outpatient buprenorphine stabilization and taper: a discrete survival and growth mixture model
Comorbid substance use diagnoses and partner violence among offenders receiving pharmacotherapy for opioid dependence
Different patterns of administration modulate propensity of methadone and buprenorphine to promote locomotor sensitization in mice
¹H NMR-based metabonomic analysis of brain in rats of morphine dependence and withdrawal intervention
Proteomic analysis of the nucleus accumbens in rhesus monkeys of morphine dependence and withdrawal intervention
(1) H-nuclear magnetic resonance-based metabonomic analysis of brain in rhesus monkeys with morphine treatment and withdrawal intervention
Financial incentives to promote extended smoking abstinence in opioid-maintained patients: a randomized trial
The effects of ibudilast, a glial activation inhibitor, on opioid withdrawal symptoms in opioid-dependent volunteers.
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands
"This is not who I want to be:" experiences of opioid-dependent youth before, and during, combined buprenorphine and behavioral treatment
Naltrexone with or without guanfacine for preventing relapse to opiate addiction in St.-Petersburg, Russia
Impact of research network participation on the adoption of buprenorphine for substance abuse treatment
Patient and program factors that bridge the detoxification-treatment gap: a structured evidence review
Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature
Emotional Impairment and Persistent Upregulation of mGlu5 Receptor following Morphine Abstinence: Implications of an mGlu5-MOPr Interaction
Pioglitazone attenuates the opioid withdrawal and vulnerability to relapse to heroin seeking in rodents
A Mixed-Method Analysis of Persisting Effects Associated with Positive Outcomes Following Ibogaine Detoxification
Contribution of psychiatric diagnoses to extent of opioid prescription in the first year post-head and neck cancer diagnosis: A longitudinal study
Sociodemographic Profiles and Clinical Outcomes for Clients on Methadone Maintenance Treatment in a Western Canadian Clinic: Implications for Practice
Subjective effectiveness of ibogaine treatment for problematic opioid consumption: Short- and long-term outcomes and current psychological functioning
Differences in Gut Microbial Diversity are Driven by Drug Use and Drug Cessation by Either Compulsory Detention or Methadone Maintenance Treatment
Modelling integrated antiretroviral treatment and harm reduction services on HIV and overdose among people who inject drugs in Tijuana, Mexico.
Comparative study between prison- and community-based treatment satisfaction for opioid use disorder in Lebanon
Therapeutic experience with tramadol for opioid dependence in a patient with chronic low back pain: a case report
Barriers to progressing through a methadone maintenance treatment programme: perspectives of the clients in the Mid-West of Ireland's drug and alcohol services
Prolonged-release opioid agonist therapy: qualitative study exploring patients' views of 1-week, 1-month, and 6-month buprenorphine formulations
The past, present and future of opioid withdrawal assessment: a scoping review of scales and technologies
Sociodemographic Profiles and Clinical Outcomes for Clients on Methadone Maintenance Treatment in a Western Canadian Clinic: Implications for Practice
GWAS-identified genetic variants associated with medication-assisted treatment outcomes in patients with opioid use disorder: a systematic review and meta-analysis protocol
The frequency of naive and early-activated hapten-specific B cell subsets dictates the efficacy of a therapeutic vaccine against prescription opioid abuse
Multimorbidity in patients enrolled in a community-based methadone maintenance treatment programme delivered through primary care
Single-Cell Glia and Neuron Gene Expression in the Central Amygdala in Opioid Withdrawal Suggests Inflammation With Correlated Gut Dysbiosis
Feasibility and Preliminary Efficacy of Isradipine During Outpatient Buprenorphine Stabilization and Detoxification: A Pilot Randomized, Placebo-Controlled Trial
Dopamine D3 receptor-based medication development for the treatment of opioid use disorder: Rationale, progress, and challenges
The effect of person, treatment and prescriber characteristics on retention in opioid agonist treatment: a 15-year retrospective cohort study.
Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.
STING Receptor Agonists
Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.
Chronic Fatigue Syndrome
Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.
Spatio-Temporal Regulation of DNA Repair
DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.
Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.
Hereditary Sensory Autonomic Neuropathy
Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.
Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.
Neural Activity: Imaging
Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.
Applications of Molecular Barcoding
The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.