Opioid growth factor suppresses expression of experimental autoimmune encephalomyelitis

Brain Research
Ian S ZagonPatricia J McLaughlin

Abstract

Naltrexone, an opioid antagonist, has been shown to modulate expression of experimental autoimmune encephalomyelitis (EAE), an animal model of MS, suggesting that endogenous opioids are inhibitory trophic factors in EAE. In the present study, we investigated the effects of one native opioid peptide, opioid growth factor ([Met(5)]-enkephalin), on the onset and progression of EAE. C57Bl/6 mice injected with myelin oligodendrocyte glycoprotein (MOG) received daily injections of 10 mg/kg OGF (MOG+OGF) or saline (MOG+Vehicle). Over 60% of the MOG+OGF animals did not exhibit behavioral signs of disease (EAE) in contrast to 100% of the mice in the MOG+Vehicle group. The severity and disease indices of EAE in the OGF-treated mice were markedly reduced from MOG+Vehicle cohorts. By day 30, 60% of MOG+OGF mice had a remission, relative to 4% in the MOG+Vehicle group. MOG-injected mice receiving OGF had significant reductions in activated astrocytes and damaged neurons compared to MOG+Vehicle animals. Unlike MOG+Vehicle and MOG+OGF mice with behavioral signs of disease, MOG+OGF animals without manifestation of disease had no lumbar spinal cord demyelination. Both OGF and OGF receptor were detected in splenic-derived T lymphocytes by immuno...Continue Reading

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Citations

Jun 6, 2012·Cell Research·Changsheng Du, Xin Xie
Aug 27, 2013·Brain Research Bulletin·Leslie A HammerPatricia J McLaughlin
Dec 14, 2018·Experimental Biology and Medicine·Ian S Zagon, Patricia J McLaughlin
Jun 14, 2017·Multiple Sclerosis Journal - Experimental, Translational and Clinical·Michael D LudwigPatricia J McLaughlin
Jun 15, 2020·European Journal of Pharmacology·Yali TuoMing Xiang
Mar 6, 2021·Frontiers in Psychiatry·Daniel JacksonBrian Johnson
Oct 11, 2011·Peptides·Richard J Bodnar
Nov 4, 2020·Brain Research Bulletin·Chirag PatelPatricia J McLaughlin

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