Opioid-induced bowel dysfunction in healthy volunteers assessed with questionnaires and MRI

European Journal of Gastroenterology & Hepatology
Matias NilssonAsbjørn Mohr Drewes

Abstract

Opioid treatment is associated with numerous gastrointestinal adverse effects collectively known as opioid-induced bowel dysfunction (OIBD). Most current knowledge of the pathophysiology derives from animal studies limited by species differences and clinical studies, which have substantial confounders that make evaluation difficult. An experimental model of OIBD in healthy volunteers in a controlled setting is therefore highly warranted. The aim of this study was to assess bowel function in healthy volunteers during opioid treatment using subjective and objective methods. Twenty-five healthy men were assigned randomly to oxycodone or placebo for 5 days in a cross-over design. The analgesic effect was assessed with muscle pressure algometry and adverse effects were measured using questionnaires including the bowel function index, gastrointestinal symptom rating scale, patient assessment of constipation symptoms and the Bristol stool form scale. Colorectal volumes were determined using a newly developed MRI method. Compared with baseline, oxycodone increased pain detection thresholds by 8% (P=0.02). Subjective OIBD was observed as increased bowel function index (464% increase; P<0.001), gastrointestinal symptom rating scale (37% ...Continue Reading

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Citations

Jan 3, 2018·Journal of Neurogastroenterology and Motility·Jakob L PoulsenAsbjørn M Drewes
Feb 7, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H HalawiM Camilleri
Jan 5, 2019·Journal of Magnetic Resonance Imaging : JMRI·Esben B MarkAsbjørn M Drewes
Oct 8, 2019·Journal of Neurogastroenterology and Motility·Anne E OlesenAsbjørn M Drewes
Feb 23, 2019·United European Gastroenterology Journal·Adam D FarmerJan Tack
Apr 3, 2019·Pharmaceutics·Sarah Sulaiman, Luca Marciani
Nov 14, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Esben Bolvig MarkAsbjørn Mohr Drewes
Oct 10, 2018·The British Journal of Radiology·Caroline HoadMaura Corsetti
Apr 4, 2021·Journal of Clinical Medicine·Ditte S KornumKlaus Krogh
Aug 15, 2021·Advanced Drug Delivery Reviews·Connor O'FarrellHannah Batchelor

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Methods Mentioned

BETA
sedation

Software Mentioned

Colometry
Matlab
SPSS

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