PMID: 16508403Mar 2, 2006Paper

Opioid-induced hyperalgesia in a murine model of postoperative pain: role of nitric oxide generated from the inducible nitric oxide synthase

Anesthesiology
E CélèrierMargarita M Puig

Abstract

Opioid-induced delayed hyperalgesia and allodynia have been reported in human and animal models. The authors evaluated the influence of different opioids used during clinical anesthesia on nociceptive sensitivity and incisional pain in mice. The role of the inducible nitric oxide synthase on surgical pain and opioid-induced pronociception also was investigated. CD1 mice were used to study the efficacy of opioids inducing pronociception and enhancing incisional pain. The implication of nitric oxide generated from the inducible nitric oxide synthase was investigated using knockout mice (C57/BL6) for its gene. Mice underwent right hind paw surgery under sevoflurane anesthesia combined with subcutaneous administration of saline or the opioids fentanyl (0.05 mg/kg), alfentanil (1 mg/kg), and remifentanil (0.04 mg/kg). Nociception was evaluated daily for 7 days using paw-pressure, plantar, and von Frey tests. The antinociceptive effect of opioids was followed by long-lasting thermal hyperalgesia and mechanical allodynia (each lasting between 2 and 7 days), but not mechanical hyperalgesia. Intraoperative infusion of opioids significantly enhanced incisional pain in all tests. The most prominent effects were observed with remifentanil....Continue Reading

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Citations

Oct 23, 2010·Der Anaesthesist·C Zöllner
Aug 9, 2012·La Radiologia medica·A F MavrogenisP Ruggieri
Sep 25, 2012·Anesthesia and Analgesia·David Cabañero, Margarita M Puig
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Dec 14, 2012·Expert Review of Neurotherapeutics·Jacob Thomas, Mark R Hutchinson
Apr 3, 2015·Headache·Peter M GraceLinda R Watkins

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