[Opioid-induced pruritus. Mechanisms and treatment regimens].

Der Anaesthesist
M Schmelz

Abstract

Substantial progress has been achieved in recent years in research on the interaction between pain and pruritus. Over and above the known inhibition of pruritus by painful stimuli (e.g. scratching), a foundation for the explanation of opioid-induced pruritus was laid through the discovery of pruritus-specific neuronal processing channels. Although traditionally the degranulating effect of opioids on mast cells was assumed to be the essential mechanism, it is now clear that opioids can also induce itching at the spinal level. Neurons of the dorsal horn of the pain system inhibit spinal itch neurons. If this inhibition is weakened by opioids, the disinhibited itch neurons become active and mediate itching, without stimulation of the primary afferent peripheral nerves. Spinal triggering of itching is observed in particular by activation of mu-opioid receptors (mu-OR), while kappa-OR surprisingly suppress itch. The therapeutic implications of this interaction will be described.

References

Dec 10, 1988·BMJ : British Medical Journal·J R Thornton, M S Losowsky
Jan 27, 1999·Journal of Pain and Symptom Management·J Katcher, D Walsh
Jun 20, 2001·European Journal of Anaesthesiology·F Kjellberg, M R Tramèr
Sep 8, 2001·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T SakaiK Sumikawa
Jul 30, 2002·QJM : Monthly Journal of the Association of Physicians·E A JonesN V Bergasa
Oct 9, 2002·Experimental Dermatology·G HeyerP Martus
Jan 2, 2003·QJM : Monthly Journal of the Association of Physicians·R TwycrossZ Zylicz
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·M C Holden KoNorah N Naughton
May 23, 2003·Anesthesia and Analgesia·Somrat CharuluxanananPissamai Promlok
Mar 27, 2004·The Journal of Pharmacology and Experimental Therapeutics·M C H KoN N Naughton
Oct 2, 2004·Dermatology : International Journal for Clinical and Investigative Dermatology·M Bigliardi-QiP L Bigliardi
Oct 7, 2004·European Journal of Pharmacology·István NagyLászló Urbán
Jan 27, 2005·The American Journal of Emergency Medicine·Peter W GreenwaldE John Gallagher
Feb 23, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·M Bigliardi-QiP L Bigliardi
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sabita RoyRoderick A Barke
Dec 31, 2005·The Journal of Investigative Dermatology. Symposium Proceedings·Desmond J Tobin, Söbia Kauser
Feb 21, 2006·Journal of the American Academy of Dermatology·Aerlyn G Dawn, Gil Yosipovitch
Mar 18, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Edward E TredgetPaul G Scott
Apr 21, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dominika LabuzHalina Machelska
May 9, 2006·European Journal of Pain : EJP·Sonja Ständer, Martin Schmelz
Jun 23, 2006·Nature Reviews. Neuroscience·Akihiko IkomaMartin Schmelz
Aug 26, 2006·Nature Clinical Practice. Nephrology·James A Delmez
Feb 23, 2007·Journal of Hepatology·Marco MarzioniAntonio Benedetti
Aug 28, 2007·Anesthesiology·Heeseung LeeMei-Chuan Ko
Jan 4, 2008·The Journal of Clinical Investigation·Andreas LefflerCarla Nau
May 6, 2008·Clinics in Liver Disease·Nora V Bergasa
Jun 25, 2008·The Clinical Journal of Pain·Larry F ChuDavid Clark
Aug 23, 2008·Journal of Opioid Management·Sukanya Mitra
Oct 10, 2008·The Journal of Pharmacology and Experimental Therapeutics·Mei-Chuan Ko, Stephen M Husbands

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neuroscience and Biobehavioral Reviews
M Schmelz
Cell
Takashi Miyamoto, Ardem Patapoutian
European Journal of Pain : EJP
Sonja Ständer, M Schmelz
© 2021 Meta ULC. All rights reserved