Opioid-induced Respiratory Depression Is Only Partially Mediated by the preBötzinger Complex in Young and Adult Rabbits In Vivo

Anesthesiology
Astrid G StuckeEckehard A E Stuth

Abstract

The preBötzinger Complex (preBC) plays an important role in respiratory rhythm generation. This study was designed to determine whether the preBC mediated opioid-induced respiratory rate depression at clinically relevant opioid concentrations in vivo and whether this role was age dependent. Studies were performed in 22 young and 32 adult New Zealand White rabbits. Animals were anesthetized, mechanically ventilated, and decerebrated. The preBC was identified by the tachypneic response to injection of D,L-homocysteic acid. (1) The μ-opioid receptor agonist [D-Ala2,N-Me-Phe4,Gly-ol]-enkephalin (DAMGO, 100 μM) was microinjected into the bilateral preBC and reversed with naloxone (1 mM) injection into the preBC. (2) Respiratory depression was achieved with intravenous remifentanil (0.08 to 0.5 μg kg(-1) min(-1)). Naloxone (1 mM) was microinjected into the preBC in an attempt to reverse the respiratory depression. (1) DAMGO injection depressed respiratory rate by 6 ± 8 breaths/min in young and adult rabbits (mean ± SD, P < 0.001). DAMGO shortened the inspiratory and lengthened the expiratory fraction of the respiratory cycle by 0.24 ± 0.2 in adult and young animals (P < 0.001). (2) During intravenous remifentanil infusion, local inje...Continue Reading

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Citations

Dec 26, 2016·Peptides·Richard J Bodnar
Mar 20, 2018·Anesthesiology·Albert DahanMarieke Niesters
Feb 17, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Peter M Lalley, Steve W Mifflin
Dec 12, 2019·Frontiers in Physiology·Aguan D Wei, Jan-Marino Ramirez
Oct 15, 2020·Physiology·Barbara PalkovicAstrid G Stucke
Apr 8, 2021·Journal of Neurophysiology·Jan-Marino RamirezErica S Levitt
Jun 3, 2021·Proceedings of the National Academy of Sciences of the United States of America·Shijia LiuSung Han
Jun 6, 2021·British Journal of Pharmacology·Jordan T BatemanErica S Levitt
Jul 6, 2021·Respiratory Physiology & Neurobiology·Elenia CinelliFulvia Bongianni

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