PMID: 9166335May 1, 1997Paper

Opioid-induced rigidity after intravenous fentanyl

Obstetrics and Gynecology
C M Viscomi, P L Bailey

Abstract

Large doses of intravenous opioids may cause severe rigidity and prevent spontaneous or controlled ventilation. The mechanism of this effect appears to be neuraxis dopamine antagonism. Rigidity after analgesic doses of fentanyl has not been reported previously. A pregnant woman receiving haloperidol for multiple psychiatric conditions presented for evaluation of vaginal bleeding. Intravenous fentanyl was administered to facilitate vaginal examination. Severe rigidity of the extremities and truncal region occurred, which prevented spontaneous or assisted ventilation. Opioid administration may result in rigidity and respiratory embarrassment. Decreased analgesic requirements in pregnancy and concomitant butyrophenone administration may predispose to opioid-induced rigidity.

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Citations

Jan 7, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Sébastien Roy, Louis-Philippe Fortier
Oct 22, 2008·Anesthesia and Analgesia·Logan J VossHeidi E Kirsch
Dec 31, 2010·Saudi Journal of Anaesthesia·Tonia C U Onyeka
May 3, 2013·Clinical Reviews in Allergy & Immunology·Joshua B RadkeTimothy E Albertson
Apr 3, 2013·Chest·Başak ÇoruhDavid R Park
Nov 20, 2002·BMC Neuroscience·Parham GharagozlouJelveh Lameh
Jan 9, 2004·Clinics in Chest Medicine·Mark D Siegel
Dec 17, 2016·Journal of Bronchology & Interventional Pulmonology·Mushtaq Ahmad, Tasleem Raza
Jan 9, 2018·Annals of Internal Medicine·Jeffrey P RoanNatalie Kandinata

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