Opioid intake prior to admission is not increased in elderly patients with low-energy fractures: A case-control study in a German hospital population

European Journal of Pain : EJP
A SchwarzerJ Vollert

Abstract

Recent studies revealed an increased prescription rate of opioids for elderly patients suffering bone fractures. To gain further insight, we conducted face-to-face interviews in the present study to compare the opioid intake between patients with low-energy fractures and patients suffering from internal diseases. In this case-control study, 992 patients, aged 60 years and older, were enrolled between March 2014 and February 2015. The interview comprised a fall and medication history, comorbidities, mobility and other risk factors for fractures. Odds ratios (OR) and a multiple logistic regression model were calculated. The number of patients with pre-admission opioid intake in the last 12 months was comparable in the fracture (n = 399, 13.3%) and the control group (n = 593, 14.7% OR: 0.89, CI: 0.62-1.29). The number of patients with current opioid intake of short duration (<3 months) was similar in both groups (14% vs. 20%; OR: 0.66, CI: 0.23-1.93). Patients with opioid intake in the fracture group reported more frequently fatigue as an adverse event of opioid medication (58% vs. 30%; OR: 3.32, CI: 1.48-7.45). Patients with opioid intake showed more severe comorbidities and significantly decreased mobility compared to those with...Continue Reading

References

Jan 1, 1991·Journal of Internal Medicine·J JensenL F Gram
Apr 20, 2001·Pharmacotherapy·M Levine, M H Ensom
May 23, 2001·Journal of Pain and Symptom Management·R AndersonC Schlicht
Aug 10, 2001·Journal of Pain and Symptom Management·J PereiraE Bruera
Apr 30, 2003·Archives of Internal Medicine·Kristine E EnsrudUNKNOWN Study of Osteoporotic Fractures Research Group
Nov 1, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·O JohnellB Jönsson
Jun 23, 2006·Journal of Internal Medicine·P VestergaardL Mosekilde
Oct 26, 2006·The American Journal of Geriatric Pharmacotherapy·Sachin J Kamal-BahlMark H Beers
Feb 4, 2009·The Journal of Pain : Official Journal of the American Pain Society·Roger ChouUNKNOWN American Pain Society-American Academy of Pain Medicine Opioids Guidelines Panel
Aug 6, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·George IoannidisJonathan D Adachi
Sep 1, 2009·European Journal of Radiology·John A KanisEugene V McCloskey
Sep 5, 2009·Der Schmerz·H ReineckeUNKNOWN German Society for the Study of Pain (DGSS)
Nov 26, 2009·Archives of Internal Medicine·John C WoolcottCarlo A Marra
Jan 6, 2010·Journal of General Internal Medicine·Kathleen W SaundersMichael Von Korff
Dec 15, 2010·Archives of Internal Medicine·Daniel H SolomonSebastian Schneeweiss
Mar 12, 2011·Journal of the American Geriatrics Society·Matthew MillerDaniel H Solomon
Jun 29, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P VestergaardL Mosekilde
Jun 5, 2013·Physiotherapy Canada. Physiothérapie Canada·Cathy M Arnold, Nancy C Gyurcsik
Jun 19, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Helena JohanssonM Carola Zillikens
Jul 3, 2013·The Journal of Spinal Cord Medicine·Laura D CarboneFrances M Weaver
Jul 9, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kristine E Ensrud
Dec 30, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Susan P DemarestRobert A Adler
Jan 15, 2015·The New England Journal of Medicine·Richard C DartJody L Green
Apr 12, 2015·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Alexander HirstRon Akehurst
May 9, 2015·Injury·Anna Gaki LindestrandStig Ejdrup Andersen
Oct 23, 2015·European Journal of Pain : EJP·U MarschallW Häuser
Jan 10, 2016·Journal of Bone and Mineral Metabolism·Frank GotthardtChristian Meier
Jan 13, 2016·Journal of General Internal Medicine·Erin E KrebsUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Mar 30, 2016·Journal of Bone and Mineral Metabolism·Fumin PingYugang Liu
Nov 20, 2016·European Journal of Pain : EJP·A HaminaS Hartikainen

❮ Previous
Next ❯

Citations

Apr 10, 2020·PloS One·Qiaoning YueZhaowei Teng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.