Opioid mediation of starch and sugar preference in the rat.

Pharmacology, Biochemistry, and Behavior
Kristine B BonacchiAnthony Sclafani

Abstract

In our prior studies, administration of the opioid receptor antagonist naltrexone did not block conditioned preferences for a flavor paired with a preferred sugar solution over a flavor paired with saccharin. This may be because both training solutions were sweet, and their attractiveness was reduced by naltrexone. The present study compared the effects of naltrexone on preferences for flavors paired with sugar or starch drinks that have distinctive tastes to rats. Experiment 1 assessed naltrexone's effect on the preference for unflavored 8% cornstarch and 8% sucrose aqueous solutions/suspensions. The food-restricted rats displayed a significant sucrose preference which increased following systemic treatment with naltrexone (1 or 3mg/kg) even though total intake of both solutions declined. In Experiment 2, rats were trained to drink flavored (cherry or grape) starch and sucrose solutions in separate one-bottle sessions. In a two-bottle choice test with both flavors presented in a sucrose-starch mixture, the rats significantly preferred the starch-paired flavor. Naltrexone treatment blocked the expression of this starch-conditioned preference. In Experiment 3, rats were treated with saline or naltrexone throughout one-bottle tra...Continue Reading

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Citations

Aug 19, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Matthew R HayesHarvey J Grill
Oct 11, 2011·Peptides·Richard J Bodnar
Apr 24, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sonja K BillesMichael A Cowley
Jun 4, 2014·Neuroreport·Florence M HerissonPawel K Olszewski
Aug 22, 2021·Current Nutrition Reports·Anica KlockarsPawel K Olszewski

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