Opioid neuropeptide genotypes in relation to heroin abuse: dopamine tone contributes to reversed mesolimbic proenkephalin expression

Proceedings of the National Academy of Sciences of the United States of America
Andrej NikoshkovYasmin L Hurd

Abstract

Striatal enkephalin and dynorphin opioid systems mediate reward and negative affect, respectively, relevant to addiction disorders. We examined polymorphisms of proenkephalin (PENK) and prodynorphin (PDYN) genes in relation to heroin abuse and gene expression in the human striatum and the relevance of genetic dopaminergic tone, critical for drug reward and striatal function. Heroin abuse was significantly associated with PENK polymorphic 3' UTR dinucleotide (CA) repeats; 79% of subjects homozygous for the 79-bp allele were heroin abusers. Such individuals tended to express higher PENK mRNA than the 81-bp homozygotes, but PENK levels within the nucleus accumbens (NAc) shell were most strongly correlated to catecholamine-O-methyltransferase (COMT) genotype. Control Met/Met individuals expressed lower PENK mRNA than Val carriers, a pattern reversed in heroin users. Up-regulation of NAc PENK in Met/Met heroin abusers was accompanied by impaired tyrosine hydroxylase (TH) mRNA expression in mesolimbic dopamine neurons. In contrast to PENK, no association was detected between PDYN genotype (68-bp repeat element containing one to four copies of AP-1 binding sites in the promoter region) and heroin abuse, although there was a clear func...Continue Reading

References

Apr 25, 1990·Nucleic Acids Research·J L Weber, P E May
Apr 25, 1990·Nucleic Acids Research·J L Weber, P E May
Jan 1, 1990·Annals of the New York Academy of Sciences·M E Wolf, R H Roth
Jun 1, 1995·Progress in Neurobiology·A ParentB Lavoie
Jan 1, 1997·Critical Reviews in Neurobiology·S N Haber, J L Fudge
May 13, 1999·Neuroreport·D E ComingsJ P MacMurray
Nov 18, 2000·Journal of Neurology·K NakanoH Ushiro
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·M F EganD R Weinberger
Jun 1, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·G DroletJ F Trottier
Jul 16, 2002·Physiology & Behavior·A E KelleyM Zhang
Jan 16, 2003·Physiology & Behavior·Susan R Sesack, David B Carr
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Venkata S MattayDaniel R Weinberger
Jun 19, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David W OslinCharles P O'Brien
Aug 12, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert M BilderAnthony A Grace
Dec 3, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Kurt F HauserToni S Shippenberg
Apr 12, 2005·Nature Neuroscience·Andreas Meyer-LindenbergKaren Faith Berman
Jul 5, 2005·Nature Reviews. Genetics·David GoldmanFrancesca Ducci
Jul 15, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrej NikoshkovGeorgy Bakalkin
Sep 27, 2005·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·John P DahlWade H Berrettini
Nov 9, 2005·PLoS Biology·Matthew V RockmanGregory A Wray
Nov 30, 2005·Psychiatric Genetics·Riju RayWade H Berrettini
Mar 7, 2006·Pharmacogenomics·Guang-Ji WangHong-Guang Xie
May 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Katarina DrakenbergYasmin L Hurd
Jul 11, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maria EllgrenYasmin L Hurd
Sep 21, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leonid YavichPekka T Männistö
Dec 1, 2000·Journal of Neurology·W Robberecht

❮ Previous
Next ❯

Citations

May 2, 2012·Human Genetics·Orna LevranMary Jeanne Kreek
Feb 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zivjena VuceticTeresa M Reyes
Nov 17, 2009·Molecular Biology and Evolution·Courtney C BabbittGregory A Wray
Feb 26, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zhicheng LinOle Isacson
Jun 23, 2012·Pharmacogenetics and Genomics·Anne Tammimäki, Pekka T Männistö
Mar 27, 2012·Genes, Brain, and Behavior·T-K ClarkeF W Lohoff
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Jibran Y KhokharRachel F Tyndale
Sep 12, 2014·Current Psychiatry Reports·Brian ReedMary Jeanne Kreek
Oct 18, 2011·Cellular and Molecular Life Sciences : CMLS·H A TejedaR Henriksson
Dec 23, 2015·The American Journal on Addictions·Jermaine D JonesSandra D Comer
Oct 11, 2012·World Neurosurgery·Nan LiGuo-dong Gao
Jul 9, 2011·Biological Psychology·Janine D FloryStephen B Manuck
Mar 9, 2011·Brain Research Bulletin·S G WeiS B Li
Oct 2, 2009·Peptides·Richard J Bodnar
Nov 28, 2015·Nucleic Acids Research·Alexey KozlenkovStella Dracheva
May 14, 2009·Hippocampus·Susanne PirkerGünther Sperk
Mar 3, 2009·The European Journal of Neuroscience·Xuqi ChenArthur P Arnold
Oct 7, 2008·Basic & Clinical Pharmacology & Toxicology·Oleg KamburEija Kalso
Jan 11, 2011·European Journal of Pain : EJP·Oleg KamburVesa K Kontinen
Aug 24, 2010·British Journal of Pharmacology·O KamburP T Männistö
Mar 6, 2010·Annals of the New York Academy of Sciences·Vadim YuferovMary Jeanne Kreek
Apr 15, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gabor EgervariYasmin L Hurd
Jun 3, 2017·Neuroscience and Biobehavioral Reviews·Gabor EgervariYasmin L Hurd
Jun 29, 2017·Journal of Clinical Pharmacy and Therapeutics·D NagayaN M Yusoff
Aug 26, 2017·Pharmacogenomics·Cynthia Marie-ClaireFlorence Vorspan
Jun 30, 2018·Molecular Psychiatry·Gabor EgervariYasmin L Hurd
Jun 13, 2018·Frontiers in Psychiatry·Bethania Mongi-BragatoLiliana M Cancela
May 1, 2021·Journal of Personalized Medicine·Lynn M OswaldCarla L Storr
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga NosovaGeorgy Bakalkin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

© 2021 Meta ULC. All rights reserved