Opioid overdose in a child: case report and discussion with emphasis on neurosurgical implications

Journal of Neurosurgery. Pediatrics
Andrew ReisnerJoshua J Chern

Abstract

In environments in which opioids are increasingly abused for recreation, children are becoming more at risk for both accidental and nonaccidental intoxication. In toxic doses, opioids can cause potentially lethal acute leukoencephalopathy, which has a predilection for the cerebellum in young children. The authors present the case of a 2-year-old girl who suffered an accidental opioid overdose, presenting with altered mental status requiring cardiorespiratory support. She required emergency posterior fossa decompression, partial cerebellectomy, and CSF drainage due to cerebellar edema compressing the fourth ventricle. To the authors' knowledge, this is the first report of surgical decompression used to treat cerebellar edema associated with opioid overdose in a child.

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Citations

Jan 5, 2018·Journal of Analytical Toxicology·M SoichotB Delhotal-Landes
Jun 12, 2018·Journal of Child Neurology·John Amaechi EmelifeonwuJegajothy Kandasamy
Aug 10, 2017·Frontiers in Neurology·Daniel DuranKristopher T Kahle
Aug 2, 2018·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Marinos Kontzialis, Thierry A G M Huisman
Jul 28, 2020·Cellular and Molecular Neurobiology·Leila Ahmad-MolaeiAbbas Haghparast

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