Opioid peptide involvement in the bulbar inhibition of electrodermal activity in the cat

Journal of Physiology, Paris
M TraoreH Sequeira

Abstract

By analogy with supraspinal and spinal inhibitory controls of pain, it was hypothesized that an opioid mechanism could be involved in the bulbar inhibitory control of the electrodermal activity. This activity was evoked as skin potential responses on the footpads of 13 cats by the central tegmental field stimulation (control responses) and inhibited by the simultaneous stimulation of bulbar reticular formation (experimental responses). Then, naloxone, an opioid peptide antagonist, was injected intravenously or intrathecally and its effects were analyzed on both control and experimental responses. Intravenous injections of naloxone increased significantly the amplitude of experimental responses from 6 to 12 min after the injection and had no effect on the amplitude of control responses. Intrathecal injections of naloxone induced significant increases of amplitude of experimental responses from 6 to 42 min after the injection. These results showed that a spinal opioid peptide link could be involved in bulbar inhibition mechanisms of electrodermal activity.

References

Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·T HökfeltG Nilsson
Apr 1, 1991·Clinical Neuropharmacology·J Lipp
Aug 1, 1987·Canadian Journal of Physiology and Pharmacology·T L Krukoff
Feb 1, 1968·Experimental Neurology·M H Bagshaw, H W Coppock
Nov 1, 1969·Journal of Comparative and Physiological Psychology·R C Wilcott
Feb 17, 1984·European Journal of Pharmacology·M N Girardot, M C Koss
Aug 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R M BowkerJ D Coulter
Jan 1, 1982·Experimental Brain Research·B DelermJ C Roy
May 1, 1981·Psychophysiology·D C FowlesP H Venables
Jun 25, 1995·Journal of the Autonomic Nervous System·H SequeiraJ C Roy
Apr 15, 1963·The Japanese Journal of Physiology·T YOKOTAB FUJIMORI
Dec 1, 1976·Physiology & Behavior·T L Yaksh, T A Rudy

❮ Previous
Next ❯

Citations

Mar 30, 2005·Autonomic Neuroscience : Basic & Clinical·Akihiro OgataTakaaki Matsumoto
Mar 4, 2000·Peptides·A L VaccarinoA J Kastin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.