PMID: 8473894May 1, 1993Paper

Opioid peptides in the rabbit carotid body: identification and evidence for co-utilization and interactions with dopamine

Journal of Neurochemistry
P R González-GuerreroC Gonzalez

Abstract

The rabbit carotid body is a catecholaminergic organ that contains dopamine and norepinephrine in a proportion of nearly 5:1. Chronic (15 days) carotid sinus nerve denervation or superior cervical ganglionectomy did not modify the carotid body dopamine content (5-6 nmol/mg of protein, equivalent to 250 pmol per carotid body), but sympathectomy reduced by approximately 50% the norepinephrine content. The carotid body has also a very high content of opioid activity (250 equivalent pmol of Leu-enkephalin/mg of protein) as measured by a radioreceptor assay that detects preferentially delta-opioid activity. In the carotid body the degree of opioid posttranslational processing to low-molecular-weight peptides (mostly Leu- and Met-enkephalin) is nearly 80%. HPLC identification of opioid peptides revealed that the sequences of Met- and Leu-enkephalin were in a proportion of nearly 6:1, indicating that the main opioid precursor in the carotid body is proenkephalin A. Chronic denervations of the carotid body did not modify the levels or the degree of opioid precursor processing. Acute hypoxic exposure of the animals (8% O2 in N2; 3 h) resulted in a parallel decrease of dopamine and opioid activity, without any change in the degree of opi...Continue Reading

References

Sep 1, 1979·Journal of Neurochemistry·C GonzalezS Fidone
Apr 1, 1992·Trends in Neurosciences·C GonzálezR Rigual
Feb 1, 1991·Brain Research·W J WangS Fidone
Jul 1, 1991·Physiological Reviews·I Kupfermann
Jul 1, 1989·Physiological Reviews·K StarkeH Kilbinger
May 1, 1989·The Journal of General Physiology·J López-LópezJ López-Barneo
Jan 1, 1987·Annual Review of Pharmacology and Toxicology·G Campbell
Jan 1, 1988·Progress in Brain Research·S J FidoneG R Hanson
Apr 16, 1986·Brain Research·A ObesoC Gonzalez
Jul 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·I M VarndellJ M Polak
Jan 1, 1980·British Journal of Pharmacology·D S McQueen, J A Ribeiro
Dec 1, 1982·The Journal of Physiology·S Fidone, C Gonzalez
Dec 1, 1982·The Journal of Physiology·S FidoneK Yoshizaki
Dec 1, 1982·The Journal of Physiology·S FidoneK Yoshizaki

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Citations

Nov 1, 1996·The European Journal of Neuroscience·T G CacheroC Gonzalez
Sep 3, 2005·Progress in Biophysics and Molecular Biology·S LahiriN R Prabhakar
Dec 15, 2019·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yoko Kameda
Mar 11, 2000·American Journal of Physiology. Cell Physiology·I VicarioC Gonzalez
May 22, 2001·The European Journal of Neuroscience·M P Morin-SurunA S Foutz
Nov 1, 1995·The American Journal of Physiology·T G CacheroC Gonzalez

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