PMID: 8938656Nov 1, 1996Paper

Opioid receptor-mediated control of acetylcholine release in human neocortex tissue

Naunyn-Schmiedeberg's Archives of Pharmacology
T J FeuersteinR Jackisch

Abstract

The effects of various opioid receptor agonists and antagonists on evoked acetylcholine release were studied in slices of human neocortex prelabelled with [3H]-choline, superfused and depolarized electrically (2 min, 3 Hz, 2 ms, 24 mA) or by K+ (20 mM). The delta-opioid receptor agonist DPDPE and the kappa-opioid receptor agonist U50488 reduced the evoked [3H]-overflow (acetylcholine release) in a concentration-dependent fashion; the delta-opioid receptor antagonist naltrindole and the kappa-opioid receptor antagonist norbinaltorphimine, respectively, antagonized these effects. Application of the mu-opioid receptor agonist DAGO also resulted in an inhibition of acetylcholine release; however, both delta- and kappa-opioid receptor antagonists were able to block this effect. The mu-opioid receptor agonists morphine and (+)-nortilidine had no effect. These results indicate that acetylcholine release in human neocortex is inhibited through delta- and kappa-opioid receptors, but not through mu-opioid receptors. Acetylcholine release was significantly increased by the delta-opioid receptor antagonist naltrindole in the presence of a mixture of peptidase inhibitors providing evidence for a delta-opioid receptor-mediated inhibition of ...Continue Reading

Citations

Oct 24, 2000·Brain Research. Developmental Brain Research·E GazyakanR Jackisch
Apr 25, 2012·Neuromolecular Medicine·Zhiyou Cai, Anna Ratka
Jun 23, 2004·Brain Research. Molecular Brain Research·Lu-Tai TienIng-Kang Ho
Dec 24, 2011·British Journal of Anaesthesia·N DietisD G Lambert
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T J FeuersteinR Jackisch

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