Abstract
Feeding is associated with increases in the activity of the mesolimbic dopamine (DA) system which originates in the ventral tegmental area (VTA) and projects heavily to the nucleus accumbens. The present study used in vivo brain microdialysis to assess the contribution of opioid receptors in feeding-evoked DA release in the nucleus accumbens. Feeding in 18 h food-deprived rats increased DA release by about 50% above baseline. Systemic injection of the opioid receptor antagonist naltrexone (1 mg/kg, s.c.) blocked the effect of feeding on DA release and reduced the amount of food consumed. Unilateral application of naltrexone (100 microM) in the VTA via a microdialysis probe failed to affect the DA response to feeding, the amount of food consumed, or the latency to eat. In contrast, intra-VTA naltrexone significantly reduced the effect of systemic heroin (0.5 mg/kg, s.c.) on accumbal DA release. These results indicate that: (1) opioid receptor activation is a component of the neural substrates of deprivation-induced feeding: (2) opioid receptors in the VTA do not contribute significantly to feeding-associated increases in DA release in the nucleus accumbens; and (3) heroin-induced increases in accumbal DA release are mediated, at...Continue Reading
References
Mar 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·R SpanagelT S Shippenberg
Nov 1, 1990·Journal of Neurochemistry·R SpanagelT S Shippenberg
May 1, 1989·Pharmacology, Biochemistry, and Behavior·S J Cooper, S Turkish
Oct 1, 1989·Behavioural Brain Research·A E KelleyC G Lang
Mar 10, 1988·Neuroscience Letters·F S RadhakishunB H Westerink
Jun 30, 1987·Brain Research·P W Kalivas, R Abhold
Aug 1, 1987·Pharmacology, Biochemistry, and Behavior·K R Evans, F J Vaccarino
May 30, 1973·Brain Research·H C FibigerE G McGeer
Nov 1, 1983·The Journal of Comparative Neurology·H KhachaturianS J Watson
Jan 1, 1982·Psychopharmacology·P WinnL J Herberg
Jun 1, 1981·The Journal of Comparative Neurology·J C FinleyP Petrusz
Citations
Oct 13, 2005·Psychopharmacology·Jose A CrespoGerald Zernig
Mar 4, 2000·Peptides·A L VaccarinoA J Kastin
Apr 18, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jose A CrespoGerald Zernig
Apr 20, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pietro CottoneEric P Zorrilla
Feb 28, 2002·Brain Research·Jonathan A HollanderRegina M Carelli
Apr 24, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sonja K BillesMichael A Cowley
Dec 3, 2014·European Journal of Pharmacology·Devki D SukhtankarMei-Chuan Ko
May 13, 2009·The International Journal of Neuropsychopharmacology·Pradeep J Nathan, Edward T Bullmore
Jul 6, 2016·Translational Psychiatry·S C WeberB B Quednow
Feb 9, 2017·Scientific Reports·Adiel MallikDaniel J Levitin
Nov 10, 2004·Brain Research·Eun-Mee KimEugene O'Hare
Jun 28, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J M Wenzel, J F Cheer
Feb 15, 2018·Journal of Dietary Supplements·Mesfin YimamQi Jia
Aug 22, 2009·Journal of Human Genetics·Kazunari IgawaAtsushi Rokutanda
Jun 6, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allison E SahrMichael A Statnick
May 24, 2019·Journal of Medicinal Food·Mesfin YimamQi Jia
May 1, 2012·Journal of Clinical Psychopharmacology·Erin N UmbergDavid J Greenblatt
Mar 3, 2007·The Journal of Pharmacology and Experimental Therapeutics·Anna RizziGirolamo Calò
May 12, 2004·Journal of Neurophysiology·M C BorrasD Borsook
Aug 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Amy F MacDonaldAllen S Levine
Feb 12, 2020·Clinical Psychological Science : a Journal of the Association for Psychological Science·Brian D KilukMehmet Sofuoglu
May 3, 2021·Translational Psychiatry·Henry K KarlssonLauri Nummenmaa