Opioid Receptors

Annual Review of Medicine
Christoph Stein

Abstract

Opioids are the oldest and most potent drugs for the treatment of severe pain. Their clinical application is undisputed in acute (e.g., postoperative) and cancer pain, but their long-term use in chronic pain has met increasing scrutiny. This article reviews mechanisms underlying opioid analgesia and other opioid actions. It discusses the structure, function, and plasticity of opioid receptors; the central and peripheral sites of analgesic actions and side effects; endogenous and exogenous opioid receptor ligands; and conventional and novel opioid compounds. Challenging clinical situations, such as the tension between chronic pain and addiction, are also illustrated.

References

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Citations

Jul 26, 2016·Frontiers in Microbiology·Alireza TahamtanVahid Salimi
Oct 27, 2016·Neuroscience·Laurie-Anne RoeckelFrédéric Simonin
Oct 13, 2016·International Journal of Pediatric Otorhinolaryngology·Maria Claudia RodríguezTatiana Castillo
Mar 8, 2017·British Journal of Pharmacology·Kristen A MarinoMarta Filizola
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Nov 14, 2018·Cell Transplantation·Shaocheng Wang
Jan 16, 2019·Der Anaesthesist·C Stein
Jan 24, 2019·The New England Journal of Medicine·J A Jeevendra MartynEdward A Bittner
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Jul 6, 2018·European Journal of Endocrinology·Athanasios FountasNiki Karavitaki
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Apr 23, 2019·The American Journal of Gastroenterology·Soumya Jagannath MahapatraPramod Kumar Garg
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Mar 15, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Diane Donegan
Dec 20, 2019·Scientific Reports·Giovanna Del VecchioChristoph Stein
Mar 14, 2020·Behavioural Pharmacology·Vicente Martínez, Raquel Abalo
Apr 14, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Biao XuQuan Fang
Apr 15, 2020·Journal of Dental Research·E V HershK N Theken
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May 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria DumitrascutaMariana Spetea
May 20, 2020·Journal of Neuroscience Research·Shangru LyuYuqing Li
Jun 4, 2020·International Journal of Molecular Sciences·Chih-Cheng WuChun-Jung Chen
Mar 30, 2016·Current Opinion in Neurology·Andrew Charles, Amynah A Pradhan
Jun 25, 2020·Expert Review of Respiratory Medicine·Alireza TahamtanVahid Salimi

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Methods Mentioned

BETA
sedation

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