Opioid-related genetic polymorphisms do not influence postoperative opioid requirement: A prospective observational study

European Journal of Anaesthesiology
Frédéric AubrunBruno Riou

Abstract

Among the various factors that may influence the pharmacological response to opioids, genetic polymorphisms [single nucleotide polymorphisms (SNP)] have generated some interest. To examine the influence on morphine dose requirements and adverse events in the postoperative period of four SNP [opioid receptor mu1 (OPRM1), ATP-binding cassette subfamily B, member 1 (ABCB1) ex-21 and ex-26, catechol-o-methyltransferase (COMT)] in candidate genes involved in morphine pharmacodynamics and pharmacokinetics. A single centre prospective study. University Hospital, Paris, France, from 2 January 2007 to 15 November 2011. A total of 438 white adults scheduled for major orthopaedic surgery (spine, hip and knee) under general anaesthesia. The main exclusion criteria were receiving opioids for chronic pain, nonopioid drugs within 2 days prior to surgery, pregnancy, renal insufficiency, sleep apnoea obstruction syndrome, morbid obesity, severe hepatic impairment, cognitive dysfunction. Assays of plasma concentrations of morphine and metabolites (morphine 3-glucuronide and morphine 6-glucuronide) were performed and common polymorphisms in four candidate genes [OPRM1 A118G rs1799971; P-glycoprotein (ABCB1) T3435C (rs1045642) and G2677T/A (rs2032...Continue Reading

References

Apr 12, 2001·European Journal of Anaesthesiology·F AubrunB Riou
Jun 27, 2003·Anesthesiology·Frédéric AubrunBruno Riou
Apr 4, 2006·Clinical Pharmacology and Therapeutics·Laurent CoulbaultLaurent Becquemont
Sep 28, 2007·Clinical Pharmacology and Therapeutics·D CampaR Barale
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Jan 11, 2012·International Journal of Immunopathology and Pharmacology·A De CaprarisM Dambrosio
Jan 18, 2012·British Journal of Anaesthesia·F AubrunB Riou
Mar 27, 2012·Pain·Martin S AngstDavid J Clark
Jun 21, 2012·Anesthesiology·Martin S AngstJ David Clark
Jun 22, 2012·Pain·Barbara A HastieRoger B Fillingim
May 21, 2013·European Journal of Clinical Pharmacology·Manuela De GregoriGuglielmina N Ranzani
Jun 4, 2013·The Journal of Pain : Official Journal of the American Pain Society·Alex T SiaEne-Choo Tan
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Aug 6, 2015·PloS One·Robert M Kaplan, Veronica L Irvin

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Citations

Dec 20, 2018·Journal of Personalized Medicine·Luis A López-Fernández
Jul 31, 2019·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Shuai ZhaoYuan Zhang
Jun 24, 2020·Peptides·Richard J Bodnar
Aug 18, 2020·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Wen-Ying Chou, Chien-Jen Hsu

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Methods Mentioned

BETA
pregnancy test
sedation
PCA
Genotyping

Clinical Trials Mentioned

NCT00822549

Software Mentioned

SAS

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