Opioid signalling in the rat rostral ventrolateral medulla

Clinical and Experimental Pharmacology & Physiology
P G GuyenetIda J Llewellyn-Smith

Abstract

1. The present article reviews several aspects of opioid signalling in the rostral ventrolateral medulla (RVLM) and their implications for the neural control of blood pressure. 2. In the RVLM, preproenkephalin (PPE) mRNA is expressed by bulbospinal cells that are strongly barosensitive. These putative presympathetic neurons includes C1 and non-C1 neurons. 3. In the RVLM, PPE mRNA is also present in GABAergic neurons that do not project to the thoracic spinal cord. 4. Rostral ventrolateral medulla presympathetic cells receive enkephalinergic inputs and express mu-opioid receptors (MOR). Some of their synaptic inputs also contain MOR. 5. Pre- and post-synaptic modulation of RVLM presympathetic neurons by MOR agonists has been demonstrated in slices of neonate brain. The post-synaptic effect is inhibitory (increased gK). Presynaptic effects include disfacilitation (reduction of glutamate release) and possibly dishinhibition (reduction of GABA release). 6. In conclusion, opioid signalling plays a pervasive role in the medullospinal network that controls sympathetic tone and arterial pressure. Opioid peptides are made by the presympathetic, presumably excitatory, cells of the RVLM and by local GABAergic inhibitory neurons. In additi...Continue Reading

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Citations

Nov 13, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Jul 25, 2003·Autonomic Neuroscience : Basic & Clinical·Stephanie C Tjen-A-LooiJohn C Longhurst
Jun 3, 2008·The European Journal of Neuroscience·Heather L ScanlinAgnieszka Balkowiec
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Aug 2, 2007·The Journal of Physiological Sciences : JPS·Hee-Young KimInsop Shim
Apr 22, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·R Frithiof, M Rundgren
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