Opioid tolerance and hyperalgesia

The Medical Clinics of North America
Grace ChangJianren Mao


Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain. This article will review updated information from both clinical and preclinical studies regarding opioid-induced hyperalgesia, tolerance, and dependence. The implications of these issues in clinical opioid therapy also will be discussed.


Oct 20, 1977·Psychopharmacology·M FernandesH Coper
Dec 1, 1979·Proceedings of the Society for Experimental Biology and Medicine·A Ho, V P Dole
Mar 14, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·M FernandesH Coper
Mar 1, 1989·Pain·David E Weissman, David J Haddox
Aug 1, 1987·Journal of Neurosurgery·R D Penn, J A Paice
Jun 10, 1998·Anesthesia and Analgesia·H R Vinik, I Kissin
Oct 15, 1998·British Journal of Anaesthesia·B J Collett
Feb 13, 2001·Pain·M DovertyWalter Ling
Aug 9, 2003·Journal of Pain and Symptom Management·Sebastiano MercadanteEdoardo Arcuri
Dec 3, 2003·The American Journal of Hospice & Palliative Care·George R Wilson, Gary M Reisfield
Jan 11, 2005·Arthritis and Rheumatism·Maren L MahowaldPeter Majeski
Jan 18, 2006·The Journal of Pain : Official Journal of the American Pain Society·Larry F ChuMartin S Angst
Feb 28, 2006·Current Pain and Headache Reports·Jianren Mao


Sep 1, 2012·The Clinical Neuropsychologist·Robert N Jamison, Robert R Edwards
Dec 22, 2007·Journal of Palliative Medicine·Solomon Liao, Robert M Arnold
Apr 6, 2013·Journal of Palliative Medicine·Shelley R SalpeterEduardo Bruera
Jan 5, 2012·Journal of Neurotrauma·Sarah A WollerMichelle A Hook
Sep 17, 2010·American Journal of Therapeutics·Mary Hanna Bekhit
Jul 28, 2011·Pancreas·Salman NusratKlaus Bielefeldt
Mar 30, 2011·Journal of Gastroenterology and Hepatology·Anwar DudekulaKlaus Bielefeldt
Jan 7, 2009·Journal of the American Board of Family Medicine : JABFM·Richard A DeyoBrook I Martin
Jan 11, 2014·Current Pain and Headache Reports·Sebastiano Mercadante
Jun 16, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Joseph ShurmanHoward B Gutstein
Jul 21, 2011·Current Medical Research and Opinion·Sebastiano Mercadante
May 2, 2015·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·James P RobinsonDennis C Turk
Sep 26, 2008·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Yakov VorobeychikJianren Mao
Aug 13, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Walter F KeanE Roderich Gossen
Jan 26, 2016·Critical Reviews in Oncology/hematology·Sebastiano Mercadante, Eduardo Bruera
Mar 20, 2012·The Journal of Pain : Official Journal of the American Pain Society·Peggy ComptonWalter Ling
Aug 23, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Spencer D DornNilay D Shah
Jun 18, 2011·The Journal of Pain : Official Journal of the American Pain Society·Robert R EdwardsRobert N Jamison
Sep 21, 2010·Metabolism: Clinical and Experimental·James P O'Callaghan, Diane B Miller
May 1, 2010·The Journal of Pain : Official Journal of the American Pain Society·C Richard ChapmanConstance M Weisner
Mar 18, 2011·Pain Practice : the Official Journal of World Institute of Pain·Alessandra GraziottinMichael N Berliner
Jan 15, 2010·Fundamental & Clinical Pharmacology·Ioanna VasileiouStamatios Theocharis
Nov 22, 2011·Paediatric Anaesthesia·Tim GearyBoris Zernikow
May 7, 2010·European Journal of Pain : EJP·Marjorie MeyerDiantha Howard
Apr 16, 2014·Pharmacoepidemiology and Drug Safety·Marsha A RaebelWilliam Troy Donahoo
Jan 15, 2015·European Journal of Pharmacology·George F Koob
Dec 4, 2014·Expert Opinion on Pharmacotherapy·Sebastiano Mercadante
Jun 12, 2013·Expert Opinion on Therapeutic Targets·Ioanna VasileiouStamatios Theocharis
Aug 2, 2015·Physical Medicine and Rehabilitation Clinics of North America·Jaymie MaiDavid Tauben
Aug 13, 2011·Journal of Pain & Palliative Care Pharmacotherapy·Chitra Ramasubbu, Anita Gupta
Dec 7, 2013·Journal of Pain & Palliative Care Pharmacotherapy·Arthur G Lipman
Dec 9, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Marino ConvertinoLuda Diatchenko
Jul 5, 2015·Mayo Clinic Proceedings·Robert N Jamison, Jianren Mao
Apr 23, 2013·Trends in Neurosciences·Jürgen Sandkühler, Jonathan Lee
Aug 6, 2013·Cell Reports·George ShapovalovNatalia Prevarskaya
Oct 18, 2011·Experimental Neurology·Lauren NicotraMark R Hutchinson

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Related Papers

Current Pain and Headache Reports
Jianren Mao
Best Practice & Research. Clinical Anaesthesiology
Wolfgang Koppert, Martin Schmelz
© 2021 Meta ULC. All rights reserved