Opioids and cardioprotection

Pharmacology & Therapeutics
J E Schultz, Garrett J Gross

Abstract

Opioid peptides and exogenous opioids such as morphine are known to exert important cardiovascular effects. However, until recently, it was not appreciated that activation of specific receptors results in a potent cardioprotective effect to reduce infarct size in experimental animals and to reduce cell death in isolated cardiomyocytes. In intact rat and rabbit hearts, nonselective opioid receptor antagonists such as naloxone and a selective delta1-opioid receptor antagonist, 7-benzylidenenaltrexone, have been shown to inhibit the cardioprotective effect of ischemic preconditioning, a phenomenon in which brief periods of ischemia protect the heart against a more prolonged period of ischemia. Selective delta(1) specific agonists such as 2-methyl-4a-alpha-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12a-alpha-octahydroquinolino[2,3,3-g]isoquinoline have been shown to exert potent cardioprotective effects in intact animals and cardiac myocytes via activation of Gi/o proteins, protein kinase C, and ultimately, the mitochondrial KATP channel. These protective effects occur immediately following drug administration, and reappear 24-48 hr post treatment. Although further studies are needed to more clearly define the mechanisms by which opioids ex...Continue Reading

References

Jun 9, 1977·Nature·J A LordH W Kosterlitz
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·S K SharmaM Nirenberg
Feb 1, 1992·Circulation Research·G J Gross, J A Auchampach
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·B L KiefferC G Hirth
Dec 28, 1992·Science·C J EvansR H Edwards
Jun 12, 1992·Brain Research·K P Mayfield, L G D'Alecy
Jul 1, 1992·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·P ParadisL Brakier-Gingras
Jan 1, 1992·Journal of Molecular and Cellular Cardiology·B A BarronJ L Caffrey
Mar 1, 1992·Brain Research Bulletin·L J Forman, O Bagasra
Jan 1, 1992·General Pharmacology·A CalignanoL Sorrentino
Jan 25, 1991·European Journal of Pharmacology·K D WildF Porreca
Nov 1, 1991·Journal of Molecular and Cellular Cardiology·K K TaiT M Wong
Jan 1, 1991·Life Sciences·S R Childers
Jan 1, 1990·Life Sciences·S Periyasamy, W Hoss
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R A GrossR L Macdonald
Sep 21, 1990·European Journal of Pharmacology·M OcañaJ M Baeyens
Sep 1, 1990·Molecular Endocrinology·K G LowM H Melner
Apr 1, 1990·Circulation Research·R J SchottW Schaper
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R A NorthM J Christie
Dec 11, 1989·Biochimica Et Biophysica Acta·C VenturaC Guarnieri
Jan 1, 1987·General Pharmacology·L MantelliF Ledda
Sep 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S LaurentT W Smith
Aug 30, 1988·Biochemical and Biophysical Research Communications·M Ouellette, L Brakier-Gingras
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R D HowellsS Udenfriend
Feb 28, 1985·Biochemical and Biophysical Research Communications·S A KruminsG Feuerstein
Jul 1, 1985·Clinical and Experimental Pharmacology & Physiology·Z Y ZhanT M Wong
May 9, 1980·Science·S J PeroutkaS H Snyder
Dec 28, 1981·Life Sciences·R S Zukin, S R Zukin
Jan 17, 1980·Nature·V Clement-JonesG M Besser

❮ Previous
Next ❯

Citations

Nov 7, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kerry ThompsonR Terry Thompson
Oct 11, 2002·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Rie Kato, Pierre Foëx
Jun 2, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Hyoung-Chan ChoYoung-Kyun Chung
Mar 29, 2005·Basic Research in Cardiology·J Vinten-JohansenF Kerendi
May 27, 2008·Basic Research in Cardiology·Jason N PeartGarrett J Gross
May 2, 2008·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Ender EllidokuzIrfan Barutça
Jun 24, 2003·Journal of Molecular and Cellular Cardiology·Garrett J Gross
Sep 12, 2003·Life Sciences·Elizabeth A EllenbergerRaymond M Quock
Jan 22, 2003·Peptides·Richard J Bodnar, Maria M Hadjimarkou
Feb 28, 2002·British Journal of Pharmacology·G F Baxter, Z Ebrahim
Dec 15, 2005·Heart, Lung & Circulation·Olivier W V van den BrinkSalvatore Pepe
Aug 30, 2003·Surgery·S RoyRoderick Barke
Mar 22, 2008·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Shahid Husain, David E Potter
Apr 29, 2009·Cardiovascular Research·Asger GranfeldtJakob Vinten-Johansen
Dec 2, 2011·Journal of Cardiovascular Pharmacology·Garrett J GrossErik Bissessar
Jun 22, 2002·Annals of the New York Academy of Sciences·Bin LiuJau-Shyong Hong
Oct 7, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Atsuko MotokiDonna M Van Winkle
Feb 3, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Craig BolteJo El J Schultz
Feb 14, 2013·Investigative Ophthalmology & Visual Science·Yasir AbdulShahid Husain
Oct 29, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Sayaka HiguchiMuhammad Ashraf
Feb 15, 2014·BioMed Research International·Ahmet Eroglu
May 8, 2013·Psychopharmacology·Richard M van RijnJennifer L Whistler
Jan 7, 2014·Heart and Vessels·Piotr SobanskiShaaban A Mousa
Apr 25, 2008·Critical Reviews in Toxicology·Edward J Calabrese
Nov 18, 2015·Genesis : the Journal of Genetics and Development·Xiaoyun CaiSarah E Ross
May 2, 2015·International Journal of Cardiology·Ioanna AndreadouEfstathios K Iliodromitis
Jan 9, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Gordon T C WongMichael G Irwin
Jul 4, 2009·Journal of Molecular and Cellular Cardiology·Craig BolteJo El J Schultz
Dec 4, 2015·Toxicology and Applied Pharmacology·Haiyan HeZhelong Xu
Sep 15, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sascha TreskatschShaaban A Mousa
Aug 14, 2009·Fundamental & Clinical Pharmacology·Shaminder KaurNirmal Singh
Feb 3, 2015·Experimental Physiology·Lindsey E MillerJohn C Quindry
Dec 19, 2014·British Journal of Pharmacology·John P HeadrickJason N Peart
Jul 28, 2004·The Annals of Thoracic Surgery·Minxin WeiMatti Tarkka
Jun 24, 2004·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Eric W DicksonKarin Przyklenk
Oct 6, 2005·Journal of Cardiothoracic and Vascular Anesthesia·Young Lan Kwak
Jun 1, 2005·Vascular Pharmacology·Jason N PeartGarrett J Gross

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.