Opioids, cocaine, and food change runtime distribution in a rat runway procedure

Psychopharmacology
Gudrun WakoniggGerald Zernig

Abstract

The nature of the relationship between the dose of a drug of abuse and its reinforcing effect has come under close scrutiny. It is currently debated if the steep ascending part of the biphasic dose-response curve typically obtained in multiple-dosing lever-press-based operant conditioning procedures represents a satiety-driven, all-or-none response or if the response is gradual and tightly adjusted to the various doses of the reinforcer. Dose-response relationships of drug reinforcers (remifentanil, alfentanil, morphine, cocaine) as well as a physiological reinforcer, i.e. food (sweetened condensed milk) were investigated in a different operant conditioning paradigm, i.e. a runway procedure. Administration of the mu opioid receptor agonists remifentanil (0.0032-0.1 mg/kg IV), alfentanil (0.032 mg/kg IV), morphine (0.032-1 mg/kg IV), the psychostimulant cocaine (0.001-0.1 mg/kg IV) or sweetened condensed milk (diluted 1:100-1:3 in water) was made contingent upon alley running for male Sprague-Dawley rats. All drug reinforcers dose-dependently decreased runtimes and, more importantly, significantly increased the percentage of runs at a certain speed (> or =10 cm/s) from an average 29% to an average 71% (water versus milk, 22% ver...Continue Reading

Citations

Apr 18, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jose A CrespoGerald Zernig
May 6, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Scott E KanoskiHarvey J Grill
Nov 13, 2004·Pharmacology·Gudrun WakoniggGerald Zernig
Jul 17, 2012·Physiology & Behavior·Carol Souza da SilvaJ Elizabeth Bolhuis
Nov 27, 2008·Pharmacology, Biochemistry, and Behavior·Aaron Ettenberg
Dec 2, 2004·Peptides·Richard J Bodnar, Gad E Klein
Oct 27, 2004·Pharmacology, Biochemistry, and Behavior·Thomas H Gomez, Richard A Meisch

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