PMID: 18407152Jul 1, 1993Paper

Opioids in neural and nonneural tissues

Trends in Endocrinology and Metabolism : TEM
A N Margioris

Abstract

The endogenous opioid peptides (EOP) are grouped in three families, each deriving from the posttranslational processing of a distinct precursor molecule and exhibiting high affinity for a specific opioid receptor. The genes of EOPs are expressed in a wide variety of sites, including many nerve, neurosecretory, and endocrine cells. In reviewing the vast literature on this subject, a few patterns begin to emerge. First, the distribution of EOPs in tissues appears to be a distinct characteristic of each family of opioids. Second, the EOP producing cells can be grouped into two broad categories: those expressing only one and those expressing multiple EOP genes. Most EOP-producing nerve and neurosecretory cells fall into the first category, that is, they express one EOP gene, whereas most nonneural cells fall into the second category, that is, they express multiple EOP genes. Third, it appears that there is a relationship between opioids, proliferation rate, and state of differentiation of cells, since it has been shown that (a) mitogenic factors may change the EOP profile of a cell, and that (b) opioids may inhibit the proliferation rate of normal or neoplastic cells. The physiologic implication of these observations is briefly dis...Continue Reading

References

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