Opioids modulate pain facilitation from the dorsal reticular nucleus

Molecular and Cellular Neurosciences
M PintoI Tavares

Abstract

During chronic pain, the supraspinal pain modulatory system undergoes plastic changes with enhancement of facilitation transmission at the spinal cord. The changes induced by chronic pain at descending modulation often affect opioidergic modulation, and were never described for a key facilitatory component of the system, the dorsal reticular nucleus (DRt). Neurochemical characterization of the DRt-spinal pathway showed that delta-opioid receptors are positioned as to indirectly modulate the activity of non-projecting DRt neurons, whereas neurons expressing mu-opioid receptors project to the spinal dorsal horn or act as interneurons, the latter of which co-expressing GABA(B) receptors. In monoarthritic rats, the expression of mu-opioid receptors decreased in the DRt whereas the levels of endogenous enkephalin remained unaltered. To increase the opioidergic inhibition of the DRt, we locally injected selective agonists of delta- and mu-opioid receptors or a viral vector containing the human preproenkephalin transgene. Injection of the Herpes Simplex viral vector encoding preproenkephalin induced thermal hypoalgesia in non-inflamed animals and hyperalgesia in monoarthritic rats. The opioid agonists [D-Ala(2), Glu(4)]-deltorphin (DE...Continue Reading

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Citations

Jun 7, 2012·Neurobiology of Disease·William F GoinsJoseph C Glorioso
Oct 2, 2009·Peptides·Richard J Bodnar
Jul 23, 2013·The European Journal of Neuroscience·Mónica Ambriz-TututiAnd René Drucker-Colín
Dec 15, 2010·Pain·Richard E LiebanoKathleen A Sluka
Jun 23, 2012·Pharmacological Reviews·Anne Estrup OlesenAsbjørn Mohr Drewes
Jul 24, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·K Bannister, A H Dickenson
Jul 21, 2017·Frontiers in Neuroanatomy·Isabel Martins, Isaura Tavares
Jan 27, 2010·Current Opinion in Supportive and Palliative Care

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