Opioids: similarity between evaluations of subjective effects and animal self-administration results

Clinical Pharmacology and Therapeutics
R R Griffiths, Robert L Balster

Abstract

Abuse potential studies of 33 morphine-like analgesics were compared in humans and monkeys. The results of intravenous self-administration studies in rhesus monkeys were correlated with measures of morphine-like signs, symptoms, and subjective effects in ex-addicts. Each set of data was assigned to a position in a 3 x 3 contingency table dependent upon whether the results were yes, no, or equivocal. Of the 33 drugs, 29 were given identical classifications in both the human and animal test procedures. This good concordance between the human and animal results further validates each procedure and suggests the possibility that both the human and animal procedures are measuring a common underlying pharmacological property which relates to abuse potential of drugs.

Citations

Dec 1, 1991·British Journal of Addiction·E M SellersU E Busto
Jan 1, 1982·Psychopharmacology·W L WoolvertonRobert L Balster
Apr 7, 2006·Journal of the Experimental Analysis of Behavior·Gail WingerTammy Wade-Galuska
Sep 13, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sietse Jonkman, Paul J Kenny
Feb 1, 1988·Agents and Actions·J L Katz, S R Goldberg
Jan 1, 1984·Psychopharmacology·R J CollinsR R Russell

Related Concepts

Metazoa
Anthropoidea
Double-Blind Method
Medicinal Plants Testing, Preclinical
Regret
Intravenous Injections
Macaca mulatta
Morphine Sulfate (2: 1), Pentahydrate
Narcotic Effect
Self Administration

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