PMID: 7992340Sep 1, 1994Paper

Opisthorchis viverrini infection in Thailand: symptoms and signs of infection--a population-based study

Transactions of the Royal Society of Tropical Medicine and Hygiene
S PungpakD Bunnag

Abstract

A population-based study of the clinical, laboratory and ultrasonographic findings in patients suffering from mild or moderate opisthorchiasis in Prachinburi province, Thailand was conducted in 1990-1992. The effectiveness of treatment with praziquantel at 40 mg/kg body weight was evaluated. After treatment, a long-lasting, marked improvement in the well-being of the study group was observed. Symptoms common in opisthorchiasis infection decreased in intensity and the clinical response showed total or partial remission in 98% of all cases studied. Total and direct bilirubin concentrations decreased significantly and remained low up to the end of the follow-up period of 2 years, indicating a reduction in cholestasis. Also, white blood cell counts decreased initially, which can be interpreted as a reduction in inflammation intensity. No relationship was found between intensity of infection and age or clinical findings. Population-based treatment of opisthorchiasis appears to have had a significant impact on public health in north-east Thailand. However, it is also evident that drug therapy alone will not solve the opisthorchiasis problem, as indicated by the reinfection rate of almost 10% at the end of the study.

References

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Jan 1, 1981·Transactions of the Royal Society of Tropical Medicine and Hygiene·D J Flavell
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Citations

Mar 1, 2012·Journal of Biomedicine & Biotechnology·Mariko MurataShosuke Kawanishi
Aug 30, 2013·Transactions of the Royal Society of Tropical Medicine and Hygiene·Jeffrey Mark ErfeJune Rose A Naig
Feb 3, 2007·Parasite Immunology·J JittimaneeS Wongratanacheewin
Jun 29, 2010·PLoS Neglected Tropical Diseases·Neil D YoungRobin B Gasser
Jul 12, 2007·PLoS Medicine·Banchob SripaPaul J Brindley
Jun 28, 2011·Parasitology International·Puangrat YongvanitHelmut Bartsch
May 17, 2018·Frontiers in Medicine·Narong KhuntikeoPaiboon Sithithaworn
Mar 2, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·Phubet SaengsawangPeter Bradshaw

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