PMID: 9183715May 1, 1997Paper

Opportunistic properties of Nosema algerae (Microspora), a mosquito parasite, in immunocompromised mice

The Journal of Eukaryotic Microbiology
T TrammerH M Seitz

Abstract

In the last ten years microsporidia have been recognized as opportunistic pathogens in AIDS patients. The sources of infection and the mechanisms of transmission of these organisms in humans are mostly uncertain. Transmission of invertebrate microsporidia to mammals is normally considered impossible, temperature being a limiting factor for development. Mice treated with cortisone acetate and with cyclosporin A, respectively, as well as athymic nice were injected intravenously, intranasally, perorally and subcutaneously with spores of Nosema algerae, a microsporidian species of culicine mosquitoes. No infection could be detected in tissue samples of cortisone acetate and cyclosporin A treated mice. However, the experimental inoculation of spores into the tail and foot of athymic mice caused severe infection in skeletal muscles and the connective tissue. In some tails, nerve tissue and bone marrow were also infected. Vegetative stages and spores were seen in direct contact to host cell cytoplasma. For the first time the prolonged and progressive development of an invertebrate microsporidium in a mammalian host is shown. The possibility of invertebrate microsporidia as a source of human microsporidiosis should now be taken into co...Continue Reading

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Citations

Nov 19, 2010·In Vitro Cellular & Developmental Biology. Animal·S Richelle MonaghanLucy E J Lee
Jul 19, 2000·International Journal for Parasitology·A Mathis
Jul 14, 1999·Diagnostic Microbiology and Infectious Disease·C Franzen, A Müller
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Jul 16, 2005·Clinical Microbiology Reviews·Alexander MathisPeter Deplazes
Jan 23, 2014·Emerging Infectious Diseases·Matthew R WattsStephen W Reddel
Nov 30, 2004·Veterinary Parasitology·E S DidierP J Didier
Jun 17, 1998·The Journal of Eukaryotic Microbiology·A CaliL M Weiss
Jul 15, 2005·The Journal of Eukaryotic Microbiology·Caspar FranzenBernd Salzberger
Oct 13, 2006·Current Opinion in Infectious Diseases·A Curry
Jul 24, 2004·Journal of Medical Microbiology·Saaeha RauzAlan Curry
Jan 26, 2005·The Journal of Eukaryotic Microbiology·Ann CaliPeter M Takvorian
Jul 18, 2018·Emerging Infectious Diseases·Gaurav SutraveMatthew R Watts
Jul 17, 1998·Journal of Clinical Microbiology·G ChioraliaH M Seitz

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