Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation

Clinical and Translational Science
Susan M KeatingKeisuke Kuida

Abstract

The high-content interrogation of single cells with platforms optimized for the multiparameter characterization of cells in liquid and solid biopsy samples can enable characterization of heterogeneous populations of cells ex vivo. Doing so will advance the diagnosis, prognosis, and treatment of cancer and other diseases. However, it is important to understand the unique issues in resolving heterogeneity and variability at the single cell level before navigating the validation and regulatory requirements in order for these technologies to impact patient care. Since 2013, leading experts representing industry, academia, and government have been brought together as part of the Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium to foster the potential of high-content data integration for clinical translation.

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Citations

Jul 2, 2019·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Christopher M HartshornPiotr Grodzinski
Feb 12, 2019·American Journal of Respiratory Cell and Molecular Biology·Katherine B HisertAnne M Manicone
Jan 14, 2020·Biosensors & Bioelectronics·Meera PunjiyaSameer Sonkusale

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Methods Mentioned

BETA
biopsy
fluorescence imaging
ELISA
feature
chip
blood draw
biopsies
flow cytometry
Assay

Software Mentioned

Spintellex
Fluidigm Hyperion Imaging System
MultiOmyx
SCA
HD

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