Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems

Experimental Biology and Medicine
David J HughesEmma L Sceats

Abstract

Liver disease represents a growing global health burden. The development of in vitro liver models which allow the study of disease and the prediction of metabolism and drug-induced liver injury in humans remains a challenge. The maintenance of functional primary hepatocytes cultures, the parenchymal cell of the liver, has historically been difficult with dedifferentiation and the consequent loss of hepatic function limiting utility. The desire for longer term functional liver cultures sparked the development of numerous systems, including collagen sandwiches, spheroids, micropatterned co-cultures and liver microphysiological systems. This review will focus on liver microphysiological systems, often referred to as liver-on-a-chip, and broaden to include platforms with interconnected microphysiological systems or multi-organ-chips. The interconnection of microphysiological systems presents the opportunity to explore system level effects, investigate organ cross talk, and address questions which were previously the preserve of animal experimentation. As a field, microphysiological systems have reached a level of maturity suitable for commercialization and consequent evaluation by a wider community of users, in academia and the pha...Continue Reading

References

Jun 1, 1997·In Vitro Cellular & Developmental Biology. Animal·Y KonoE A Roberts
Feb 3, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K Jungermann, T Kietzmann
May 1, 2002·JAMA : the Journal of the American Medical Association·Karen E LasserDavid H Bor
Feb 7, 2004·Biotechnology Progress·Kwanchanok ViravaidyaMichael L Shuler
Feb 24, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jeffrey A SunmanAngela D M Kashuba
Dec 14, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jared W AllenSangeeta N Bhatia
Jun 28, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·David J HughesUday K Tirlapur
Nov 21, 2007·Nature Biotechnology·Salman R Khetani, Sangeeta N Bhatia
Dec 5, 1992·Biotechnology and Bioengineering·A RotemM L Yarmush
Jul 17, 2009·Lab on a Chip·Keil J RegehrDavid J Beebe
Jul 30, 2009·Expert Opinion on Drug Metabolism & Toxicology·Ajit DashSteven R Tannenbaum
Nov 21, 2009·Biochemical Pharmacology·Eric NovikMartin L Yarmush
Dec 19, 2009·The Journal of Pharmacology and Experimental Therapeutics·Robert A Roth, Patricia E Ganey
Dec 22, 2009·Lab on a Chip·Karel DomanskyLinda G Griffith
Dec 30, 2009·Electrophoresis·Jinwen ZhouNicolas Hans Voelcker
Jun 12, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Patrick J ShawRobert A Roth
Jul 3, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Wendy WeiWei WangR Scott Obach
Aug 27, 2010·The Journal of Clinical Investigation·S Tamir RashidLudovic Vallier
Apr 10, 2012·Annals of Biomedical Engineering·Jack D WangMohamed ElSayed
May 16, 2012·Critical Reviews in Toxicology·Edward L LeCluyseMark J Powers
Nov 9, 2012·Science Translational Medicine·Dongeun HuhDonald E Ingber
Nov 13, 2012·Archives of Toxicology·S MessnerJ M Kelm
Nov 16, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Salman R KhetaniYvonne Will
Feb 6, 2013·IEEE Transactions on Bio-medical Engineering·John P WikswoStacy D Sherrod
Jul 6, 2013·Lab on a Chip·John P WikswoWilliam J Matloff
Aug 21, 2013·Lab on a Chip·Karel DomanskyDonald E Ingber
Aug 21, 2013·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tom S ChanDonald Tweedie
Dec 18, 2013·Toxicology and Applied Pharmacology·Franck A AtienzarStéphane Dhalluin
Feb 26, 2014·Stem Cell Research & Therapy·Gordana Vunjak-NovakovicKaren Hirschi
Mar 13, 2014·Advanced Drug Delivery Reviews·Mohammad R EbrahimkhaniLinda G Griffith
May 14, 2014·Experimental Biology and Medicine·Amanda M ClarkAlan Wells
Jul 30, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Aurelie VivaresSylvie Klieber
Dec 20, 2014·Journal of Laboratory Automation·Jin-Young KimOlivier Frey
Jan 17, 2015·Journal of Biotechnology·Jin-Young KimOlivier Frey
Jan 27, 2015·Atherosclerosis·Nwe Ni Than, Philip N Newsome
Mar 6, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·Hasan Erbil Abaci, Michael L Shuler

❮ Previous
Next ❯

Citations

Aug 18, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Shyam Sundhar Bale, Jeffrey T Borenstein
Aug 24, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Pedro Caetano-Pinto, Simone H Stahl
Sep 20, 2020·Bioengineering·Vanessa AllwardtVirginia Pensabene
Jan 8, 2020·Hepatology Communications·Tomasz KostrzewskiDavid Hughes
Apr 10, 2019·Biotechnology and Bioengineering·Shyam Sundhar BaleJoseph L Charest
Feb 6, 2021·Trends in Biotechnology·Nathalie Picollet-D'hahanSéverine Le Gac
Dec 19, 2020·Nature Reviews. Gastroenterology & Hepatology·Albert GoughD Lansing Taylor
Jun 10, 2018·Advanced Drug Delivery Reviews·Alexa WnorowskiJoseph C Wu
May 1, 2021·Micromachines·Merve UstunSavas Tasoglu
May 14, 2021·Clinical and Translational Science·Hongbing WangShiew-Mei Huang
Aug 12, 2021·Clinical and Translational Science·Kirk P Van NessEdward J Kelly
Sep 3, 2021·Journal of Biomaterials Applications·Dganit Stern-TalElla Sklan

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

TissUse
InSphero
MPS
Nortis
Hurel
Emulate

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.