Abstract
Within current oncology practice, several genomic applications are being used to inform treatment decisions with molecularly targeted therapies in breast, lung, colorectal, melanoma, and other cancers. This commentary introduces a conceptual framework connecting the full spectrum of biomedical research disciplines, including fundamental laboratory research, clinical trials, and observational studies in the translation of genomic applications into clinical practice. The conceptual framework illustrates the contribution that well-designed observational epidemiologic studies provide to the successful translation of these applications, and characterizes the role observational epidemiology plays in driving the dynamic and iterative bench-to-bedside, and bedside-to-bench translation continuum. We also discuss how the principles of this conceptual model, emphasizing integration of multidisciplinary research, can be applied to the evolving paradigm in "precision oncology" focusing on multiplex tumor sequencing, and we identify opportunities for observational studies to contribute to the successful and efficient translation of this paradigm.Cancer Epidemiol Biomarkers Prev; 24(3); 484-9. ©2015 AACR.
References
Jul 28, 1990·Lancet·L LennardR M Weinshilboum
May 12, 1989·Science·D J SlamonA Ullrich
Nov 7, 1985·Nature·M M NauJ D Minna
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Y KokaiM I Greene
Sep 1, 1986·Clinical Pharmacology and Therapeutics·L LennardJ S Lilleyman
Jan 1, 1987·Clinical Pharmacology and Therapeutics·L LennardR M Weinshilboum
Jan 9, 1987·Science·D J SlamonW L McGuire
Oct 31, 1985·The New England Journal of Medicine·R C SeegerD Hammond
Oct 1, 1983·British Journal of Clinical Pharmacology·L LennardJ L Maddocks
Mar 15, 2001·The New England Journal of Medicine·D J SlamonL Norton
Feb 25, 2005·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·Julian LittleMarta Gwinn
Apr 19, 2006·Cancer Research·Astrid LièvrePierre Laurent-Puig
Jan 10, 2008·JAMA : the Journal of the American Medical Association·Steven H Woolf
Jan 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Astrid LièvrePierre Laurent-Puig
Mar 5, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rafael G AmadoDavid D Chang
Oct 24, 2008·The New England Journal of Medicine·Christos S KarapetisJohn R Zalcberg
Jul 17, 2009·Pharmacogenomics·Felix W Frueh
Sep 10, 2009·Journal of the National Cancer Institute·Salvatore SienaAlberto Bardelli
Jun 30, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Amy P AbernethySharon B Murphy
Mar 1, 2009·Personalized Medicine·Ilia L FerrusiKathryn A Phillips
Aug 7, 2010·American Journal of Epidemiology·Muin J KhouryJohn P A Ioannidis
Jul 8, 2011·Science Translational Medicine·Francis S Collins
Dec 6, 2011·Cancer Discovery·Elizabeth A PlatzWilliam G Nelson
Dec 14, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George W Sledge
May 16, 2012·Cancer Discovery·Margaret R SpitzAndrew N Freedman
Feb 21, 2013·Clinical Pharmacology and Therapeutics·M V RellingT E Klein
Mar 30, 2013·Science·Bert VogelsteinKenneth W Kinzler
Apr 17, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stefan SleijferLillian L Siu
Apr 17, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Levi A Garraway
Jan 22, 2014·Nature Reviews. Clinical Oncology·Jeff Shrager, Jay M Tenenbaum
Apr 2, 2014·Nature Reviews. Clinical Oncology·Richard L Schilsky
May 23, 2014·JAMA : the Journal of the American Medical Association·Mark G KrisPaul A Bunn
Jun 11, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Richard L SchilskyClifford A Hudis
Citations
Nov 27, 2015·Surgical Oncology·Travis J Meyers, Frederick J Meyers
Oct 16, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lee W Jones
Apr 6, 2019·Frontiers in Oncology·Rebecca F HalperinSara A Byron
Jun 2, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·M SchootmanN O Davidson
Mar 15, 2021·Pharmacoepidemiology and Drug Safety·Amalia M IssaGillian Bartlett
May 13, 2021·Scientific Reports·M SchootmanN O Davidson