Opportunities to implement a sustainable genomic medicine program: lessons learned from the IGNITE Network.

Genetics in Medicine : Official Journal of the American College of Medical Genetics
Kenneth D LevyGeoffrey S Ginsburg

Abstract

While there is growing scientific evidence for and significant advances in the use of genomic technologies in medicine, there is a significant lag in the clinical adoption and sustainability of genomic medicine. Here we describe the findings from the National Human Genome Research Institute's (NHGRI) Implementing GeNomics In pracTicE (IGNITE) Network in identifying key constructs, opportunities, and challenges associated with driving sustainability of genomic medicine in clinical practice. Network members and affiliates were surveyed to identify key drivers associated with implementing and sustaining a genomic medicine program. Tallied results were used to develop and weigh key constructs/drivers required to support sustainability of genomic medicine programs. The top three driver-stakeholder dyads were (1) genomic training for providers, (2) genomic clinical decision support (CDS) tools embedded in the electronic health record (EHR), and (3) third party reimbursement for genomic testing. Priorities may differ depending on healthcare systems when comparing the current state of key drivers versus projected needs for supporting genomic medicine sustainability. Thus we provide gap-filling guidance based on IGNITE members' experien...Continue Reading

References

Feb 2, 2011·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Bruce R Korf
Mar 1, 2012·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Stephanie M FullertonGail P Jarvik
May 24, 2013·Journal of Human Genetics·Christina G Perry, Alan R Shuldiner
Sep 27, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Felix W Frueh
Dec 18, 2013·Pharmacogenomics·Susanne B Haga
Jan 6, 2016·BMC Medical Genomics·Kristin Wiisanen WeitzelUNKNOWN IGNITE Network
Apr 14, 2017·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Kathryn A PhillipsMichael P Douglas
Jun 18, 2017·Journal of Pharmaceutical Sciences·Michelle E KleinJae-Gook Shin
Sep 16, 2017·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Lori A OrlandoLaura J Damschroder

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Citations

Oct 17, 2018·Medical Teacher·Hilliard Jason
Jul 4, 2019·Journal of Personalized Medicine·Rachele M Hendricks-SturrupChristine Y Lu
Jun 1, 2019·Journal of the American College of Clinical Pharmacy : JAACP·J Kevin HicksJames C Lee
Aug 30, 2020·Journal of the American Academy of Child and Adolescent Psychiatry·Laura B RamseyJeffrey R Strawn
Oct 30, 2020·Genes·Hetanshi NaikStuart A Scott
Jan 12, 2021·Clinical Pharmacology and Therapeutics·J Kevin HicksUNKNOWN IGNITE Pharmacogenetics Working Group
May 1, 2021·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Nicholas J KeelingMeagen Rosenthal
May 12, 2020·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Patricia A DeverkaKathryn A Phillips
Jul 27, 2021·Journal of Genetic Counseling·Talia S SchwartzIngrid A Holm
Aug 7, 2021·Journal of Personalized Medicine·Nina R SperberLori A Orlando
Oct 3, 2021·Human Genetics·Evangelia Eirini TsermpiniGeorge P Patrinos
Aug 20, 2021·Pharmacogenetics and Genomics·Tyler ShuggJasmine A Luzum

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Software Mentioned

IGNITE
GeNomics
IGNITE Toolbox

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