Opportunity Costs of Receiving Palliative Chemotherapy for Metastatic Pancreatic Ductal Adenocarcinoma.

JCO Oncology Practice
Erin M BangeRonac Mamtani

Abstract

The median overall survival (OS) for metastatic pancreatic ductal adenocarcinoma (mPDAC) is < 1 year. Factors that contribute to quality of life during treatment are critical to quantify. One factor-time spent obtaining clinical services-is understudied. We quantified total outpatient time among patients with mPDAC receiving palliative systemic chemotherapy. We conducted a retrospective analysis using four patient-level time measures calculated from the medical record of patients with mPDAC receiving 5-fluorouracil infusion, leucovorin, oxaliplatin, and irinotecan; gemcitabine/nab-paclitaxel; or gemcitabine within the University of Pennsylvania Health System between January 1, 2011 and January 15, 2019. These included the total number of health care encounter days (any day with at least one visit) and total visit time. Total visit time represented the time spent receiving care (care time) plus time spent commuting and waiting for care (noncare time). We performed descriptive statistics on these outpatient time metrics and compared the number of encounter days to OS. A total of 362 patients were identified (median age, 65 years; 52% male; 78% white; 62% received gemcitabine plus nab-paclitaxel). Median OS was 230.5 days (7.6 mon...Continue Reading

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Citations

Sep 22, 2020·Cancer Medicine·Gabrielle B RocqueKelly M Kenzik
Sep 17, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Evan T HallLidia Schapira
Mar 5, 2021·JCO Oncology Practice·Rahul BanerjeeArjun Gupta
Oct 29, 2021·JCO Oncology Practice·Arjun GuptaMuhammad S Beg

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