Opposed expression of IKKα: loss in keratinizing carcinomas and gain in non-keratinizing carcinomas

Oncotarget
Desheng XiaoYongguang Tao

Abstract

The functional role of IKKα in vivo is pretty complicated, largely due to its diverse functions through cell autonomous and non-autonomous manners. In addition, most of the studies on IKKα were derived from animal models, whether these findings hold true in human tumors remain unclear. Here we examined the expression of IKKα in nasopharyngeal carcinoma, which includes non-keratinizing carcinoma and keratinizing squamous cell carcinoma, and lung squamous cell carcinoma with keratinization and non-keratinization. We demonstrated that IKKα expression was almost negative in keratinizing cancer and higher expression of IKKα was found in non-keratinizing cancer, and that IKKα expression correlated with cellular differentiation of tumors in non-keratinizing nasopharyngeal carcinoma. These findings demonstrate that IKKα is diversely expressed in keratinizing and non-keratinizing carcinomas in the same type of cancer.

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Citations

Jul 31, 2016·Chinese Journal of Cancer·Shuang Liu, Yong-Guang Tao
Dec 4, 2019·Life Science Alliance·Evangelia ChavdoulaKenneth B Marcu
Apr 19, 2017·Tuberculosis and Respiratory Diseases·Hye Jung ParkYoon Soo Chang
Mar 31, 2018·Biomedicines·Georgios S MarkopoulosEvangelos Kolettas

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Methods Mentioned

BETA
biopsies

Software Mentioned

SPSS

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