Opposing effects of AMPA and 5-HT1A receptor blockade on passive avoidance and object recognition performance: correlation with AMPA receptor subunit expression in rat hippocampus

Neuropharmacology
Lucio SchiapparelliD Frechilla

Abstract

It has been suggested that antagonists at serotonin 5-HT1A receptors may exert a procognitive effect by facilitating glutamatergic neurotransmission. Here we further explored this issue by looking for the ability of a 5-HT1A antagonist to prevent the learning deficit induced by AMPA receptor blockade in two behavioural procedures in rats, and for concomitant molecular changes presumably involved in memory formation in the hippocampus. Pretraining administration of the competitive AMPA receptor antagonist, NBQX, produced a dose-related retention impairment in a passive avoidance task 24h later, and also impaired retention in a novel object recognition test when an intertrial interval of 3h was selected. Pretreatment with the selective 5-HT1A receptor antagonist, WAY-100635, prevented the learning deficit induced by NBQX in the two behavioural procedures. In biochemical studies performed on rat hippocampus after the retention tests, we found that learning increased the membrane levels of AMPA receptor GluR1 and GluR2/3 subunits, as well as the phosphorylated forms of GluR1, effects that were abolished by NBQX administration before the training session. Pretreatment with WAY-100635 counteracted the NBQX effects and restored the in...Continue Reading

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Citations

Mar 26, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Luis EscribanoDiana Frechilla
Jul 7, 2012·Progress in Neurobiology·José Julio RodríguezAlexei Verkhratsky
Dec 8, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Simone BoerBrian Dean
Aug 4, 2015·Behavioural Brain Research·Alicia A WalfCheryl A Frye
Jul 22, 2008·Behavioural Brain Research·Bríd A Nic Dhonnchadha, Kathryn A Cunningham
Aug 19, 2008·Behavioural Brain Research·Herbert Y Meltzer, Tomiki Sumiyoshi
Apr 9, 2008·Behavioural Brain Research·Sven Ove OgrenOliver Stiedl
Feb 5, 2008·Behavioural Brain Research·Martín CammarotaIván Izquierdo
Mar 21, 2007·Neuroscience and Biobehavioral Reviews·Ekrem DereMaria A De Souza Silva
Apr 10, 2007·Neuroscience and Biobehavioral Reviews·Alfredo Meneses, Georgina Perez-Garcia
Dec 27, 2008·Biochemical and Biophysical Research Communications·Luis EscribanoDiana Frechilla
Feb 23, 2010·Pharmacology, Biochemistry, and Behavior·Miguel SkirzewskiPedro Rada
Dec 6, 2016·Learning & Memory·Katherine LeaderbrandJelena Radulovic

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