PMID: 8605254Feb 7, 1996Paper

Opposing effects of nitroxide free radicals in Escherichia coli mutants deficient in DNA repair

Biochimica Et Biophysica Acta
G WangA Samuni

Abstract

Nitroxide free radicals have been previously shown to function as superoxide dismutase (SOD) mimics and to protect bacterial and mammalian cells against oxidative damage, particularly from superoxide and hydrogen peroxide. Although nitroxides are generally considered to be non-toxic nor mutagenic, there is no agreement regarding their potential adverse effect. Some toxic effects were observed upon using high concentration of six-membered ring derivatives. Conflicting evidence has also been reported regarding the mutagenic activity of nitroxides toward Salmonella typhimurium. It was also demonstrated that nitroxides exert two opposing effects on exonuclease III deficient cells of Escherichia coli upon exposure to naphthoquinones. The attempts to use nitroxides as contrast agents in nuclear magnetic resonance imaging (MRI) and as a new class of anti-oxidants underscore the need to examine their potential adverse effects. Since nitroxides protected xthA cells from DNA scission caused by H2O2, it was anticipated that they would provide even greater protection for recA DNA repair-deficient cells of E. coli, which are more sensitive to H2O2-induced oxidative stress. The results of the present study showed that: (a) nitroxides exert b...Continue Reading

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Citations

Oct 18, 2000·Free Radical Biology & Medicine·M B GariboldiE Monti
Mar 26, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M B GariboldiE Monti
Oct 31, 1998·Biochimica Et Biophysica Acta·K JungG Martini

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