Opposing influences of glucocorticoids and interleukin-1beta on the secretion of growth hormone and ACTH in the rat in vivo: role of hypothalamic annexin 1

British Journal of Pharmacology
J G PhilipJ C Buckingham

Abstract

1. This study exploited established immunoneutralization protocols and an N-terminal annexin 1 peptide (annexin 1(Ac2 - 26)) to advance our knowledge of the role of annexin 1 as a mediator of acute glucocorticoid action in the rat neuroendocrine system in vivo. 2. Rats were treated with corticosterone (500 microg kg(-1), i.p.) or annexin 1(Ac2 - 26) (0.1 - 10 ng rat(-1), i.c.v.) and 75 min later with interleukin 1beta (IL-1beta, 10 ng rat(-1), i.c.v. or 500 microg kg(-1), i.p). Blood was collected 1 h later for hormone immunoassay. Where appropriate, anti-annexin 1 polyclonal antiserum (pAb) was administered subcutaneously or centrally prior to the steroid challenge. 3. Corticosterone did not affect the resting plasma corticotrophin (ACTH) concentration but suppressed the hypersecretion of ACTH induced by IL-1beta (i.p. or i.c.v.). Its actions were quenched by anti-annexin 1 pAb (s.c. or i.c.v) and mimicked by annexin 1(Ac2 - 26). 4. By contrast, corticosterone provoked an increase in serum growth hormone (GH) which was ablated by central but not peripheral administration of anti-annexin 1 pAb. IL-1beta (i.c.v. or i.p.) did not affect basal GH but, when given centrally but not peripherally, it abolished the corticosterone-induc...Continue Reading

References

Sep 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D W Brann, V B Mahesh
Dec 1, 1991·Clinical Endocrinology·C MuruaisC Diéguez
Jan 1, 1990·The Journal of Clinical Endocrinology and Metabolism·F F CasanuevaC Dieguez
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R M EvansM G Rosenfeld
Jun 12, 1995·European Journal of Pharmacology·J G HarrisM Perretti
Feb 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A M Van DamF Berkenbosch
May 14, 1998·Clinical Endocrinology·C PelliniG Chiumello
Jun 18, 1998·Annals of the New York Academy of Sciences·S M McCannV Rettori
Jul 25, 2000·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·A Mulla, J C Buckingham

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Citations

Mar 30, 2004·Trends in Endocrinology and Metabolism : TEM·Christopher D JohnJulia C Buckingham
Nov 11, 2003·Trends in Pharmacological Sciences·Mauro Perretti
Jan 29, 2003·Current Opinion in Pharmacology·Christopher D John, Julia C Buckingham
Dec 7, 2013·PloS One·Rand T AkashehGiamila Fantuzzi
Oct 11, 2008·Current Opinion in Pharmacology·Christopher D JohnJulia C Buckingham
Aug 12, 2003·Cell Biochemistry and Function·Julia C BuckinghamJohn Morris
Sep 4, 2014·American Journal of Physiology. Endocrinology and Metabolism·Isabel Daufenback MachadoSandra Helena Poliselli Farsky
Dec 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Robert HannonRoderick J Flower
Aug 26, 2004·American Journal of Physiology. Endocrinology and Metabolism·Maarten O van AkenFerdinand Roelfsema
Feb 12, 2008·Trends in Pharmacological Sciences·Egle SolitoGlenda E Gillies

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