Opposing Roles of Estradiol and Testosterone on Stress-Induced Visceral Hypersensitivity in Rats

The Journal of Pain : Official Journal of the American Pain Society
Yaping JiRichard J Traub

Abstract

Chronic stress produces maladaptive pain responses, manifested as alterations in pain processing and exacerbation of chronic pain conditions including irritable bowel syndrome. Female predominance, especially during reproductive years, strongly suggests a role of gonadal hormones. However, gonadal hormone modulation of stress-induced pain hypersensitivity is not well understood. In the present study, we tested the hypothesis that estradiol is pronociceptive and testosterone is antinociceptive in a model of stress-induced visceral hypersensitivity (SIVH) in rats by recording the visceromotor response to colorectal distention after a 3-day forced swim (FS) stress paradigm. FS induced visceral hypersensitivity that persisted at least 2 weeks in female, but only 2 days in male rats. Ovariectomy blocked and orchiectomy facilitated SIVH. Furthermore, estradiol injection in intact male rats increased SIVH and testosterone in intact female rats attenuated SIVH. Western blot analyses indicated estradiol increased excitatory glutamate ionotropic receptor NMDA type subunit 1 expression and decreased inhibitory metabotropic glutamate receptor 2 expression after FS in male thoracolumbar spinal cord. In addition, the presence of estradiol du...Continue Reading

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Citations

Oct 31, 2018·Nature Reviews. Urology·Mats HolmbergCecilia Dhejne
Mar 11, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Yaping JiRichard J Traub
Jun 16, 2019·Environmental Science and Pollution Research International·Yuanyuan WeiXiuhui Zhong
Nov 18, 2018·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Birgit SchauerJuliane Schwille-Kiuntke
Mar 12, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Jinghong ChenJohn H Winston
Apr 23, 2021·The Journal of Pain : Official Journal of the American Pain Society·Dong-Yuan CaoRichard J Traub
Jun 4, 2021·Journal of Pain Research·Ting XiangDong-Yuan Cao
Jun 8, 2021·Frontiers in Endocrinology·Sik Yu So, Tor C Savidge
Jul 14, 2021·Pain·Ann M GregusMatthew W Buczynski

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