Opposite associations of carbohydrate-deficient transferrin and gamma-glutamyltransferase with prevalent coronary heart disease

Archives of Internal Medicine
Pekka JousilahtiPekka Sillanaukee

Abstract

Moderate alcohol consumption may reduce the risk of coronary heart disease (CHD), but excessive alcohol consumption is probably harmful to the heart. We analyzed the association of 2 commonly used markers of alcohol consumption-carbohydrate-deficient transferrin (CDT) and gamma-glutamyltransferase (GGT)-and self-reported alcohol consumption with prevalent CHD. The study included a random sample of 3666 Finnish men aged 25 to 74 years who participated in a risk factor survey in 1997. The cross-sectional association of CDT, GGT, and self-reported drinking with CHD was analyzed by means of logistic regression models. The CDT level was inversely and GGT level positively associated with CHD risk. The odds ratios (adjusted for age, smoking, total and high-density lipoprotein cholesterol levels, systolic blood pressure, and body mass index) of CHD among men in the fourth quartiles of CDT and GGT, as compared with the first quartiles, were 0.69 and 1.76, respectively. In a composite risk assessment, men with normal CDT levels (< or =20 U/L) and elevated GGT levels (>80 U/L) had nearly 8-fold adjusted risk of CHD as compared with the men with normal GGT levels and elevated CDT levels. Self-reported alcohol consumption had an inverse ass...Continue Reading

Citations

May 1, 2007·Future Cardiology·Michele EmdinAlfonso Pompella
Nov 24, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Alfonso PompellaAldo Paolicchi
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Tao Liu
May 18, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ted J Kaptchuk
May 18, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Wayne B Jonas
Apr 19, 2008·The Journal of Medicine and Philosophy·Oron Frenkel
Feb 27, 2004·Addiction·Katherine M ConigraveJohn B Whitfield
Mar 24, 2005·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Katja BorodulinPekka Jousilahti
Mar 24, 2020·Journal of the American Heart Association·Inge A T van de LuitgaardenJoline W J Beulens
May 29, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Setor K KunutsorStephan J L Bakker

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