Opposite changes in meteorin-like and oncostatin m levels are associated with metabolic improvements after bariatric surgery

International Journal of Obesity : Journal of the International Association for the Study of Obesity
S PelliteroD Sánchez-Infantes

Abstract

Bariatric surgery is currently the most effective therapy for type 2 diabetes. However, the mechanisms underlying its beneficial effects remain elusive. Here we studied the effects of bariatric surgery on circulating meteorin-like (Metrnl) and oncostatin m (OSM) levels, two hormones intimately linked to energy homeostasis. Metrnl and OSM levels were assessed at baseline, 6 and 12 months after laparoscopic sleeve gastrectomy (LSG) in 25 patients with obesity, as well as in 33 normal-weight controls. At baseline, patients with obesity showed lower Metrnl and higher OSM levels compared to controls. LSG increased Metrnl and decreased OSM levels, in correlation to improvements in glucose and lipid homeostasis. Our data indicate that LSG conversely modulated Metrnl and OSM levels, and suggest that a dual approach modulating these two molecules might provide a novel strategy for obesity and type 2 diabetes treatment.

References

Oct 20, 2009·The Journal of Clinical Endocrinology and Metabolism·Judith Aron-WisnewskyKarine Clément
Apr 27, 2012·The Journal of Clinical Endocrinology and Metabolism·G H E J VijgenW D van Marken Lichtenbelt
Dec 4, 2013·The Journal of Clinical Endocrinology and Metabolism·David Sanchez-InfantesJacqueline M Stephens
May 23, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·B RachidL A Velloso
May 26, 2016·Diabetes Care·David E Cummings, Ricardo V Cohen

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Citations

Nov 6, 2018·Journal of Cellular and Molecular Medicine·Zheng-Xia LiuXiang Lu
Feb 7, 2019·Physiology·Magdalene K MontgomeryMatthew J Watt
Jul 2, 2020·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Rulin DenizSuleyman Aydin
Jun 27, 2020·Annals of Clinical Biochemistry·Lei LiChengkun Qin
Nov 23, 2018·Archives of Physiology and Biochemistry·Reza FadaeiKhodayar Ghorban
Oct 2, 2020·Acta Pharmacologica Sinica·Zhu-Wei MiaoChao-Yu Miao
Feb 27, 2021·The Journal of Experimental Medicine·Celia RupérezAnna Planavila
Aug 19, 2021·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Christoph GranderHerbert Tilg
Nov 23, 2021·Journal of Cachexia, Sarcopenia and Muscle·Juan CaiWei Gao

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