Opposite effects of acute versus chronic naltrexone administration on ethanol-induced locomotion

Behavioural Brain Research
Carla Sanchis-SeguraC M Aragon

Abstract

Several studies have pointed out that the mu opioid receptor (MOR) can play a key role in some of the behavioural effects of ethanol. In the present study, the implication of the MOR in ethanol-induced locomotion in mice was assessed. First, the effects of the administration of different naltrexone doses (0.001-1.000 mg/kg) on the locomotor changes produced by ethanol (2.5 g/kg) were evaluated. In a second set of experiments, the ability of repeated naltrexone (6 mg/kg) administrations to modify the effects of ethanol was also assessed on mice locomotion. The results of the present study revealed that an acute naltrexone administration reduced dose-dependently ethanol-induced locomotion. Conversely, after repeated naltrexone injections, a transient boost of ethanol induced locomotor activity was observed. Thus, the results of the present study revealed that the effects of these naltrexone pretreatments on ethanol-induced locomotion are similar to the previously described changes on MOR activity. Moreover, the same (acute and chronic) naltrexone pretreatments produced similar changes on the locomotion of mice after a challenge with morphine (a MOR agonist), but not after tert-butanol (an alcohol which does not release beta-endor...Continue Reading

References

Aug 1, 1991·Japanese Journal of Pharmacology·H KuribaraS Tadokoro
Nov 7, 1989·European Journal of Pharmacology·B C YoburnK Lutfy
Oct 1, 1987·Pharmacology, Biochemistry, and Behavior·M T Bardo, J L Neisewander
May 1, 1986·Pharmacology, Biochemistry, and Behavior·J C Crabbe, D M Dorsa
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·G V MiltonC K Erickson
Dec 1, 1994·Alcoholism, Clinical and Experimental Research·J P de WaeleC Gianoulakis
Aug 1, 1994·Alcoholism, Clinical and Experimental Research·B C Dudek, T Tritto
Jan 1, 1997·Psychopharmacology·A Herz
Jun 1, 1997·Alcoholism, Clinical and Experimental Research·T J PhillipsJ D Dorow
May 20, 1998·Pharmacology, Biochemistry, and Behavior·C AlvarezJ Boada
Jul 11, 1998·Alcoholism, Clinical and Experimental Research·D D RasmussenC W Wilkinson
Apr 21, 1999·Brain Research Bulletin·M D Madeira, M M Paula-Barbosa
Sep 16, 1999·Alcohol·Carla Sanchis-SeguraC M Aragon
Oct 18, 2000·European Journal of Pharmacology·J M Van ReeC L Van den Berg
May 10, 2001·The International Journal of Neuropsychopharmacology·Rosana CamariniHelena Maria Calil
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Alok DeDipak K Sarkar
Sep 18, 2002·Drug and Alcohol Dependence·Carla Sanchis-Segura, Carlos M G Aragon
Mar 26, 2003·The European Journal of Neuroscience·Heidi M B LesscherMirjam A F M Gerrits

❮ Previous
Next ❯

Citations

Aug 27, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maria N Arizzi-LaFranceJohn D Salamone
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Raúl Pastor, Carlos M G Aragon
Jun 24, 2010·Behavioural Pharmacology·Adam StewartAllan V Kalueff
Dec 21, 2004·Alcoholism, Clinical and Experimental Research·Raúl PastorCarlos M G Aragon
Sep 13, 2005·Alcoholism, Clinical and Experimental Research·Carla Sanchis-SeguraMichael S Cowen
Apr 1, 2006·Alcoholism, Clinical and Experimental Research·Sami P OjanenKalervo Kiianmaa
Feb 8, 2005·Neuroscience Letters·Carla Sanchis-SeguraCarlos M G Aragon
Jul 26, 2005·Peptides·Richard J Bodnar, Gad E Klein
May 28, 2014·Neuropharmacology·Juan Carlos LedesmaCarlos M G Aragon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.