PMID: 8580531Jan 1, 1995Paper

Opposite effects of interleukin-2 (IL-2) and interferon gamma (IFN gamma) on rat atria contractility

Acta Physiologica, Pharmacologica Et Therapeutica Latinoamericana : órgano De La Asociación Latinoamericana De Ciencias Fisiológicas Y [de] La Asociación Latinoamericana De Farmacología
M M de BraccoL Sterin-Borda

Abstract

We have recently shown that interleukin 2 (IL-2) can increase the contractile strength or rat atrial muscle through the activation of phospholipases and protein kinase C. The results of this study confirm that the reaction of IL-2 with rat atria involves protein kinase C and not the Ca(++)-calmodulin dependent kinases. Phorbol 12-myristate 13-acetate (PMA), a tumor promoter that activates protein kinase C directly (bypassing the phosphoinositide turnover step), has effects that are similar to those of IL-2 on atrial contractility. Furthermore, preincubation of the tissue with PMA prevents the IL-2 effect, suggesting that the kinases activated by the tumor promoter and IL-2 share a common substrate. This effect of IL-2 on atrial contractility opposes the cholinomimetic inhibitory action of IFN gamma. Thus, preincubation of cardiac tissue with IL-2 or PMA eliminates the effects of IFN gamma and viceversa. Apparently, the inhibitory action of IL-2 on IFN gamma involves an impaired response or atria to cholinergic activation, as IL-2 shifts to the right the dose response curve of the tissue to the cholinergic muscarinic agonist carbachol. Protein kinase C is also necessary for the occurrence of the IL-2-IFN gamma interference. The ...Continue Reading

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