Opposite effects of intraventricular serotonin and bufotenin on rat startle responses.

Pharmacology, Biochemistry, and Behavior
M A GeyerA J Mandell

Abstract

Rat startle responses to air puffs were monitored in a stabilimeter during the intraventricular infusion of various doses of 5-hydroxytrptamine (5-HT) or the putative hallucinogenic congener of 5-HT, 5-hydroxy-N, N-dimethyltrytamine (5-HDMT) or saline. Qualitativity opposite effects were observed, with 5-HT producing a dose-dependent decrease in responsivity and 5-HDMT increasing the magnitude of startle responses. No specific effects of either compound could be demonstrated on the presumably separable processes of sensitization and habituation. The results are discussed in the context of a central serotonergic system which facilitates behavioral inhibition and which is antagonized by indoleamine hallucinogens.

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Citations

Dec 17, 2010·Psychopharmacology·Sarah CorcoranErica Duncan
Feb 1, 1979·Pharmacology, Biochemistry, and Behavior·M A GeyerL R Petersen
May 1, 1980·Pharmacology, Biochemistry, and Behavior·J D WarbrittonJ E Fischer
Jun 1, 1986·Pharmacology, Biochemistry, and Behavior·F BengtssonB Jeppsson
Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·A S EisonL A Riblet
Jun 1, 1989·Pharmacology, Biochemistry, and Behavior·L P SheetsL W Reiter
Jan 1, 1981·Neuroscience and Biobehavioral Reviews·R A Glennon, J A Rosecrans
Jul 1, 1996·Journal of Psychoactive Drugs·T LyttleJ Gartz
Nov 4, 2000·Journal of Psychoactive Drugs·M C McBride
Jan 1, 1981·Pharmacology, Biochemistry, and Behavior·M Vergnes, E Kempf
Jul 5, 2005·Neurotoxicology and Teratology·Susan M MelnickDiana L Dow-Edwards

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