Opposite effects of iv amiodarone on cardiovascular vagal and sympathetic efferent activities in rats

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Valdo Jose Dias Da SilvaNicola Montano

Abstract

It is unknown whether amiodarone exerts a direct central action on the cardiovascular autonomic nervous system. This study was designed to evaluate the effects of acute amiodarone administration on vagal and sympathetic efferent nerve discharges. Experiments were carried out in 25 decerebrate unanesthetized rats. In one group, vagal activity was recorded from preganglionic fibers isolated from the cervical vagus nerve. In another group, sympathetic recordings were obtained from fibers isolated from the cervical sympathetic trunk in intact conditions or after barodenervation. Recordings were performed before and for 60 min after amiodarone (50 mg/kg iv) administration. In all groups, amiodarone induced bradycardia and hypotension. Vagal activity increased immediately, reaching a significant difference after 20 min (260 +/- 131% from 16.4 +/- 3.3 spikes/s) and was unmodified by the barodenervation. At difference, sympathetic activity after an initial and short-lasting increase (150 +/- 83% from 24.8 +/- 5.7 spikes/s) began to decrease significantly after 20 min (36 +/- 17%) throughout the experiment. The initial increase in sympathetic activity was not observed in barodenervated animals. These changes in vagal and sympathetic act...Continue Reading

References

Dec 1, 1986·Journal of Pharmacokinetics and Biopharmaceutics·S J Weir, C T Ueda
Nov 1, 1980·American Heart Journal·A MallianiA Zanchetti
Mar 1, 1982·Journal of Cardiovascular Pharmacology·E RivaA Guaitani
May 1, 1982·Journal of Cardiovascular Pharmacology·W B GoughN El-Sherif
May 1, 1983·The Journal of Clinical Investigation·H O GloorT N James
Oct 1, 1996·Journal of Cardiovascular Electrophysiology·P Coumel
May 1, 1997·Journal of the American College of Cardiology·P R KoweyR A Filart
Sep 16, 1999·The New England Journal of Medicine·P J KudenchukT Walsh
Nov 11, 1999·Circulation·S J Connolly
Nov 24, 1999·The American Journal of Cardiology·I KodamaJ Toyama
Jan 12, 2001·Journal of the American College of Cardiology·F LombardiC Fiorentini

❮ Previous
Next ❯

Citations

Apr 5, 2012·Experimental Diabetes Research·Patricia FiorinoVera Farah
Aug 3, 2010·Autonomic Neuroscience : Basic & Clinical·Takashi OhoriHiroshi Inoue
Aug 17, 2005·Journal of Cardiovascular Electrophysiology·Terry B J KuoCheryl C H Yang
Mar 1, 2012·Experimental Physiology·Valdo Jose Dias da SilvaNicola Montano
May 24, 2005·International Journal of Cardiology·Diego F DávilaCarmen A Mazzei de Dávila
Sep 26, 2006·Experimental Neurology·Mariana MorrisVera Farah
Jun 24, 2015·Cardiovascular Research·Valdo Jose Dias da SilvaAntonio Zaza
May 1, 2009·Autonomic Neuroscience : Basic & Clinical·Eleonora TobaldiniNicola Montano
Jun 4, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·P F OliveiraH C Salgado
Jul 25, 2007·Clinical and Experimental Pharmacology & Physiology·Helio C SalgadoRubens Fazan
May 22, 2018·Pacing and Clinical Electrophysiology : PACE·Henriette Elena Fortes SilvaDalmo Correia
Jun 10, 2004·Thyroid : Official Journal of the American Thyroid Association·Joyce R SilvaLaura S Ward
Dec 20, 2002·Nature·Kevin J Tracey
Jun 11, 2020·Journal of Neural Engineering·Jessica D FalconeHarbaljit S Sohal
May 2, 2019·Veterinary World·Worakan BoonhohSuwanakiet Sawangkoon
Nov 23, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nebojša MujovićTatjana S Potpara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.