Opposite effects of lorazepam on two kinds of myoclonus in the photosensitive Papio papio

Electroencephalography and Clinical Neurophysiology
A ValinR Naquet

Abstract

The action of lorazepam was studied in photosensitive baboons. Animals were either naturally very photosensitive or rendered photosensitive by a previous injection of allylglycine. Intravenous administration of varying doses, from 0.05 to 0.5 mg/kg, of lorazepam blocked the myoclonus induced by intermittent light stimulation in all the animals. However, in the naturally photosensitive baboon the injection of lorazepam favoured the appearance of spontaneous myoclonus with no important EEG modification. This myoclonus is different from that induced by intermittent light stimulation, which is always preceded by spike-wave cortical discharges. Lorazepam-induced myoclonus appears during the period when the animal is not photosensitive and its origin is probably in the medulla or in the brain stem.

References

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Citations

Jan 1, 1991·Movement Disorders : Official Journal of the Movement Disorder Society·S Brailowsky
Feb 1, 1995·Italian Journal of Neurological Sciences·R NaquetC Menini
Feb 1, 1985·Electroencephalography and Clinical Neurophysiology·C Cepeda, R Naquet
Aug 1, 1991·Electroencephalography and Clinical Neurophysiology·I RektorC Ménini
Jan 20, 2004·CNS Drugs·Félix Javier Jiménez-JiménezMaría de Toledo-Heras
Jan 1, 1993·Movement Disorders : Official Journal of the Movement Disorder Society·I RektorC Menini

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