Opposite effects of protein kinase C beta1 (PKCbeta1) and PKCepsilon in the metastatic potential of a breast cancer murine model

Breast Cancer Research and Treatment
Valeria C GrossoniAlejandro J Urtreger

Abstract

In this paper we investigated whether protein kinase C (PKC) beta1 and PKCepsilon, members of the classical and novel PKC family, respectively, induce phenotypic alterations that could be associated with tumor progression and metastatic dissemination in a murine model of breast cancer. Stable overexpression of PKCbeta1 in LM3 cells altered their ability to proliferate, adhere, and survive, and impaired their tumorigenicity and metastatic capacity. Moreover, PKCbeta1 induced the re-expression of fibronectin, an extracellular matrix glycoprotein which loss has been associated with the acquisition of a transformed phenotype in different cell models, and exerted an important inhibition on proteases production, effects that probably impact on LM3 invasiveness and dissemination. Conversely, PKCepsilon overexpression enhanced LM3 survival, anchorage-independent growth, and caused a significant increase in spontaneous lung metastasis. Our results suggest PKCbeta1 functions as an inhibitory protein for tumor growth and metastasis dissemination whereas PKCepsilon drives metastatic dissemination without affecting primary tumor growth.

References

Jan 1, 1984·Cancer Metastasis Reviews·E Ruoslahti
Dec 1, 1995·The Journal of Biological Chemistry·A C Newton
Aug 19, 1993·International Journal of Cancer. Journal International Du Cancer·J JuarezD Boyd
Feb 1, 1994·Trends in Biochemical Sciences·L V Dekker, P J Parker
Nov 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P C GordgeW R Miller
Apr 1, 1997·Current Opinion in Cell Biology·A C Newton
Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·P A AndreasenM J Duffy
Jun 26, 1998·The Biochemical Journal·H Mellor, P J Parker
Oct 1, 1998·International Journal of Cancer. Journal International Du Cancer·A UrtregerA F Muro
Jul 17, 1999·European Journal of Biochemistry·J A Aguirre GhisoE B de Kier Joffè
Jul 27, 1999·International Journal of Cancer. Journal International Du Cancer·A J UrtregerE Bal de Kier Joff
May 7, 2002·Nature Reviews. Cancer·Mikala Egeblad, Zena Werb
Aug 16, 2002·Connective Tissue Research·Wen LinWen-Mei Fu
Jul 17, 2003·International Journal of Cancer. Journal International Du Cancer·Stella Maris RanuncoloLydia Puricelli
Nov 17, 2004·Molecular Carcinogenesis·Alejandro J UrtregerElisa D Bal de Kier Joffé
Mar 12, 2005·World Journal of Gastroenterology : WJG·Elzbieta SkrzydlewskaStanislaw Sulkowski
Aug 3, 2005·Matrix Biology : Journal of the International Society for Matrix Biology·Yong Mao, Jean E Schwarzbauer
Aug 19, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Kirsty A Green, Leif R Lund
Oct 6, 2005·Cancer Research·Roderick P RegalaAlan P Fields
Dec 13, 2005·The Journal of Biological Chemistry·Luowei LiStuart H Yuspa
Mar 27, 2007·Nature Reviews. Cancer·Erin M Griner, Marcelo G Kazanietz

❮ Previous
Next ❯

Citations

May 23, 2013·Pancreas·Stéfano M CiriglianoAlejandro J Urtreger
Dec 18, 2013·Oncogene·R GargM G Kazanietz
Sep 4, 2015·Journal of Cellular Biochemistry·Damián E BerardiLaura B Todaro
Nov 19, 2011·IUBMB Life·Alejandro J UrtregerElisa D Bal de Kier Joffé
Jul 18, 2015·Cancers·Catríona M Dowling, Patrick A Kiely
Oct 27, 2017·Oncotarget·Catríona M DowlingPatrick A Kiely
Nov 13, 2013·Cancers·Atta GoudarziIrene L Andrulis
May 30, 2015·Molecular Cancer Research : MCR·Alvaro Gutierrez-UzquizaMarcelo G Kazanietz
Oct 12, 2020·Advances in Biological Regulation·Peter J Parker Silvia Martini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Tumorigenesis

Breast tumorigenesis involves the production or formation of tumor(s) in breast tissue. Discover the latest research on breast tumorigenesis here.