PMID: 9184798May 1, 1997Paper

Opposite effects of sex steroids on 11 beta-hydroxysteroid dehydrogenase activity in the normal and adrenalectomized rat testis

General Pharmacology
K H NweB A Khalid

Abstract

1. Sex steroids have been shown to regulate the biosynthesis of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD). 2. In vitro studies showed that oestradiol (E2) or testosterone (T) can interfere with the bioassay of enzyme activity, but not progesterone (P4). 3. For in vivo studies, the activity of 11 beta-HSD in the testis of normal and adrenalectomized (ADX) adult male Wistar rats was determined following a daily IM injection of sex steroids for 7 days. 4. The 11 beta-HSD activity was significantly reduced (P < 0.01) either by E2 or T in normal and ADX rats. The enzyme activity in normal rats given both T and E2 was even lower (P < 0.001) than when E2 was given alone. 5. P4 given to normal and ADX rats increased the enzyme activity higher than normal (P < 0.001). 6. The presence of corticosteroids influenced the effects of E2, but not of T and P4, on 11 beta-HSD activity. 7. E2 and T downregulate 11 beta-HSD activity, whereas P4 increased it. E2 did not act through lowering T level.

References

Jul 1, 1979·Acta Endocrinologica·T J McKennaD Rabin
Aug 1, 1991·The Journal of Clinical Endocrinology and Metabolism·M M Hammami, P K Siiteri
Feb 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·R E Smith, J W Funder
Jul 1, 1989·Endocrinology·D M PhillipsC Monder
Nov 1, 1966·Endocrinology·D R Koerner
Jan 1, 1972·Annual Review of Biochemistry·E V Jensen, E R DeSombre
Sep 1, 1983·The Journal of Clinical Endocrinology and Metabolism·D C CummingS S Yen
Apr 1, 1983·Journal of Steroid Biochemistry·B ZumoffD K Fukushima
Jan 1, 1980·Annual Review of Physiology·B S Katzenellenbogen
Apr 1, 1993·Molecular and Cellular Endocrinology·W MercerZ Krozowski

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Citations

Sep 13, 2012·BMC Complementary and Alternative Medicine·Ahmad Nazrun ShuidIma Nirwana Soelaiman
Aug 28, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Halimatun Saadiah Abdul RazakIsa Naina Mohamed
Sep 12, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Abdul Shukor Tajul AriffAhmad Nazrun Shuid
Sep 30, 2010·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Ahmad Nazrun ShuidIma Nirwana Soelaiman
Mar 6, 2003·American Journal of Physiology. Endocrinology and Metabolism·Jennifer Slone WilcoxonEva E Redei

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