Opposite effects of short- and long-term fatty acid infusion on insulin secretion in healthy subjects

Diabetologia
G PaolissoF D'Onofrio

Abstract

Our study investigates short- and long-term effects of infusion of non-esterified fatty acids (NEFA) on insulin secretion in healthy subjects. Twelve healthy individuals underwent a 24-h Intralipid (10% triglyceride emulsion) infusion at a rate of 0.4 ml/min with a simultaneous infusion of heparin (a bolus of 200 U followed by 0.2 U/min per kg body weight). After an overnight fast (baseline), at 6 and at 24 h of Intralipid infusion and 24 h after Intralipid discontinuation (recovery test), all subjects underwent an intravenous glucose tolerance test (iv-GTT) (25 g of glucose/min). Intralipid infusion caused a threefold rise in plasma NEFA concentrations with no difference between the 6- and the 24-h concentrations. Compared to baseline acute insulin response (AIR) (AIR = 63 +/- 8 mU/l), short-term (6-h) Intralipid infusion was associated with a significant increase in AIR (86 +/- 12 mU/l p < 0.01); in contrast, long-term (24-h) Intralipid delivery was associated with inhibition of AIR (31 +/- 5 mU/l) compared to baseline (p < 0.001) and to the 6-h (p < 0.03) triglyceride emulsion infusion. Intralipid infusion was associated with a progressive and significant decline in respiratory quotient (RQ). A positive correlation between c...Continue Reading

References

Sep 1, 1975·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C Berne
Jan 1, 1988·The American Journal of Clinical Nutrition·K R SegalT B Van Itallie
Jan 1, 1986·Diabetes/metabolism Reviews·K S Polonsky, A H Rubenstein
Jul 1, 1974·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R GobernaE F Pfeiffer
Aug 1, 1973·The Journal of Clinical Investigation·S R CrespinD Steinberg
Jan 1, 1969·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·W J MalaisseI M Mandelbaum
Sep 1, 1994·Diabetologia·P J RandleA Halsall

❮ Previous
Next ❯

Citations

Mar 20, 2003·Current Diabetes Reports·Richard E Pratley, Christian Weyer
Jul 1, 1997·Diabetes Research and Clinical Practice·F GregorioP Filipponi
Jul 13, 2000·The British Journal of Nutrition·V Grill, E Qvigstad
Jul 20, 2007·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L LionettiS Iossa
Nov 1, 2001·Diabetes, Obesity & Metabolism·P Arner
Jun 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kristin D JeffreyJames D Johnson
Feb 21, 2006·Antioxidants & Redox Signaling·Gustav Mattiasson, Patrick G Sullivan
May 22, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Daniël H van RaalteMichaela Diamant
Nov 5, 2010·Diabetes, Obesity & Metabolism·G Las, O S Shirihai
Nov 5, 2010·Diabetes, Obesity & Metabolism·M CnopD A Cunha
May 22, 2008·American Journal of Physiology. Endocrinology and Metabolism·Sylvia Santosa, Michael D Jensen
Dec 25, 2008·American Journal of Physiology. Endocrinology and Metabolism·B SalginD B Dunger
Jan 7, 2005·Nutrition & Metabolism·Zahra Fatehi-Hassanabad, Catherine B Chan
Dec 1, 2007·Endocrine Reviews·Vincent Poitout, R Paul Robertson
Dec 4, 2008·The Journal of Clinical Endocrinology and Metabolism·Michael D Jensen
Oct 1, 2011·The Journal of Clinical Endocrinology and Metabolism·Ximena LopezAllison B Goldfine
Dec 24, 2011·PloS One·Srikarthika JambunathanVishwajeet Puri
Jan 31, 2002·Journal of Endocrinological Investigation·A CavarapeA Ceriello
Jun 15, 2014·The Journal of Endocrinology·Craig S NunemakerPoonam R Sharma
Mar 31, 2015·Expert Opinion on Therapeutic Targets·Lara BelliniHervé Le Stunff
Sep 28, 2005·Expert Opinion on Investigational Drugs·Kathryn Aston-MourneySofianos Andrikopoulos
Sep 1, 2011·Diabetes Research and Clinical Practice·Daniel H van Raalte, Michaela Diamant
Sep 1, 2009·Biochimica Et Biophysica Acta·Vincent PoitoutGhislaine Fontés
Jul 23, 2005·International Journal of Clinical Practice. Supplement·R A DeFronzo
Jan 30, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·A H HealdI Laing

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.