PMID: 7535931Mar 28, 1995Paper

Opposite effects of transforming growth factor alpha and epidermal growth factor on mouse placental lactogen I secretion

Proceedings of the National Academy of Sciences of the United States of America
M YamaguchiF Talamantes

Abstract

This study was undertaken to determine whether transforming growth factor alpha (TGF-alpha) regulates the production of mouse placental lactogen I (mPL-I) and mPL-II in a manner that is similar to that of epidermal growth factor (EGF), which was previously shown to stimulate mPL-I secretion and inhibit mPL-II secretion. In contrast to the activity of EGF, human (h) and rat (r) TGF-alpha (each at 100 ng/ml) inhibited secretion of mPL-I by placental cells isolated from mice on day 7 of pregnancy. Maximum inhibition of mPL-I secretion occurred on the third day of a 5-day culture period and ranged between 37% and 56% in multiple trials. Incubation of cells with hTGF-alpha and EGF was not followed by a change in the mPL-I concentration of the medium, suggesting the peptides antagonized each other's effects. hTGF-alpha and rTGF-alpha inhibited secretion of mPL-II; maximum inhibition ranged between 62% and 84% in multiple trials. The lowest concentrations of hTGF-alpha that affected mPL-I and mPL-II secretion were 10 ng/ml and 1 ng/ml, respectively. EGF and hTGF-alpha bound to the same receptors on placental cells, as assessed by cross-linking, and both peptides stimulated receptor phosphorylation, as assessed by Western blot analysis...Continue Reading

References

Oct 20, 1992·Biochimica Et Biophysica Acta·T J VaughanK D Brown
Dec 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M YamaguchiF Talamantes
Nov 1, 1985·The Journal of Clinical Investigation·P H SternG J Strewler
Jan 1, 1971·Analytical Biochemistry·R T Hinegardner
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P ColosiF Talamantes
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M YamaguchiF Talamantes

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Citations

Dec 16, 2003·Molecular and Cellular Biology·Tristan A RodriguezSally L Dunwoodie
Oct 1, 1996·Journal of Endocrinological Investigation·M YamaguchiA Miyake
Sep 1, 1996·Journal of Endocrinological Investigation·M Yamaguchi, A Miyake

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