Opposite modulation of cocaine-seeking behavior by D1- and D2-like dopamine receptor agonists

Science
D W SelfE J Nestler

Abstract

Activation of the mesolimbic dopamine system is known to trigger relapse in animal models of cocaine-seeking behavior. We found that this "priming" effect was selectively induced by D2-like, and not by D1-like, dopamine receptor agonists in rats. Moreover, D1-like receptor agonists prevented cocaine-seeking behavior induced by cocaine itself, whereas D2-like receptor agonists enhanced this behavior. These results demonstrate an important dissociation between D1- and D2-like receptor processes in cocaine-seeking behavior and support further evaluation of D1-like receptor agonists as a possible pharmacotherapy for cocaine addiction.

References

Jun 1, 1977·Pharmacology, Biochemistry, and Behavior·D C RobertsH C Fibiger
Jan 11, 1979·Nature·J W Kebabian, D B Calne
Aug 1, 1977·The British Journal of Psychiatry : the Journal of Mental Science·R H Belmaker, D Wald
Jun 12, 1992·Brain Research·D W Self, L Stein
Sep 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D LévesqueP Sokoloff
Feb 11, 1992·Trends in Pharmacological Sciences·D R Sibley, F J Monsma
Jan 1, 1992·Psychopharmacology·R N EhrmanC P O'Brien
Jun 12, 1990·European Journal of Pharmacology·P H Andersen, J A Jansen
Jan 1, 1989·Psychopharmacology·J H JaffeM A Sherer
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·S H SnyderJ W Daly
Jan 1, 1981·Psychopharmacology·H de Wit, J Stewart
Aug 19, 1983·Science·N E Goeders, J E Smith
May 1, 1980·Pharmacology, Biochemistry, and Behavior·D C RobertsH C Fibiger
Jan 1, 1993·Psychopharmacology·M R WeedW L Woolverton
Feb 1, 1994·Trends in Pharmacological Sciences·C H Large, C M Stubbs

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Citations

Jan 6, 2000·The Journal of Experimental Zoology·H YamamotoN Fusetani
May 13, 2004·Naunyn-Schmiedeberg's Archives of Pharmacology·Natasa MilivojevicMarko Zivin
May 2, 2003·Psychopharmacology·David H Epstein, Kenzie L Preston
May 2, 2003·Psychopharmacology·Michela MarinelliFrancis J White
Jun 15, 2007·Psychopharmacology·Ayelet CooperAbraham Zangen
May 16, 2008·Psychopharmacology·Gunnar SørensenDavid P D Woldbye
Jul 31, 2009·Psychopharmacology·Ryan K Bachtell, David W Self
May 23, 2012·Molecular Neurobiology·Jing WuLing-Qiang Zhu
Jun 18, 2005·Brain Research. Brain Research Reviews·Christian A HeidbrederCharles R Ashby
Jun 12, 2013·Neuropharmacology·James David Jentsch, Zachary T Pennington
Apr 6, 2004·Trends in Pharmacological Sciences·Eric J Nestler
Nov 14, 1997·Biological Psychiatry·B A JohnsonC Clyde
Jul 26, 2002·Brain Research·Andrew B NormanVladimir L Tsibulsky
Nov 26, 2002·Brain Research·Irina V Zhdanova, Marco Giorgetti
Apr 9, 2002·European Journal of Pharmacology·Roman StefanskiSteven R Goldberg
Dec 29, 1998·European Journal of Pharmacology·M Graziella De MontisJ E Smith
Feb 10, 2000·European Journal of Pharmacology·C N HaileV L Coffin
Jul 6, 2000·Pharmacology, Biochemistry, and Behavior·T N FerraroW H Vogel
Mar 27, 2001·Pharmacology, Biochemistry, and Behavior·R S Sinnott, M A Nader
Aug 31, 2001·Pharmacology, Biochemistry, and Behavior·C M KnappC Kornetsky
Aug 15, 2002·Pharmacology, Biochemistry, and Behavior·Rita A FuchsJanet L Neisewander
Aug 1, 1997·Pharmacology, Biochemistry, and Behavior·A L Chausmer, A Ettenberg
Jul 1, 1997·Pharmacology, Biochemistry, and Behavior·M J Kreek
Jan 27, 1998·Pharmacology, Biochemistry, and Behavior·A BecharaD van der Kooy
Mar 18, 1999·Pharmacology, Biochemistry, and Behavior·R M Philpot, C L Kirstein
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·R D SpealmanT V Khroyan
Sep 3, 2002·Neuroscience and Biobehavioral Reviews·Tangui MauriceRae R Matsumoto
Aug 23, 2002·Pharmacology & Therapeutics·A Lê, Y Shaham
Sep 1, 2000·Brain Research. Brain Research Reviews·Y ShahamJ Stewart
Dec 22, 1998·Brain Research. Brain Research Reviews·K C Berridge, T E Robinson
Jan 19, 2000·Trends in Pharmacological Sciences·A R Childress, C P O'Brien

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