PMID: 9187326May 9, 1997Paper

Opposite modulatory effects of ovarian hormones on rat brain dopamine and serotonin transporters

Brain Research
G AttaliM Rehavi

Abstract

The present study was designed to investigate the modulatory effect of gonadal steroids on brain dopamine (DA) and serotonin (5-HT) presynaptic transporters in female and male rats. Female and male rats were castrated and treated with either vehicle or gonadal hormones. The pharmacodynamic characteristics of the DA and 5-HT transporters were analyzed by [3H]BTCP and [3H]imipramine binding respectively. Ovariectomy (OVX) resulted in an upregulation of the striatal DA transporter and this alteration was prevented by estradiol (E2) or E2 + progesterone (P) treatment but not by P alone. In contrast to the DA transporter, the hypothalamic 5-HT transporter was down-regulated by OVX in female rats and this decrease was reversed by the administration of E2, P or their combination. The striatal DA transporter and the hypothalamic 5-HT transporter in male rat were not affected by orchidectomy or by administration of testicular hormone. Our findings indicate that ovarian, but not testicular, steroid hormones may play an important role in the regulation of brain DA and 5-HT transporters. It appears that ovarian hormones modulate rat brain 5-HT and DA transporters in opposite directions. These interactions between ovarian steroids and presy...Continue Reading

Citations

Mar 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·F Scott HallG R Uhl
Jul 16, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Suneet MehrotraAntoinette MaassenVanDenBrink
Oct 16, 2015·Behavioural Pharmacology·Filip TylšJiří Horáček
Feb 4, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J G P PiresH A Futuro Neto
Mar 15, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Erika Estrada-CamarenaCarolina López-Rubalcava
Mar 5, 1999·Molecular Neurobiology·C L BetheaZ N Lu
Feb 3, 2006·Journal of Neuroendocrinology·M Le Saux, T Di Paolo
Mar 7, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Saloua BenmansourAlan Frazer
Oct 23, 2013·Pharmacological Reports : PR·Mohammad N AlamAftab Ahmad
Sep 6, 2011·Journal of Psychopharmacology·Erika Estrada-CamarenaOfir Picazo
Oct 25, 2007·Headache·Andrew G Herzog
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Nov 18, 2006·Neuroscience and Biobehavioral Reviews·Kelly Allott, Jennifer Redman
Oct 31, 2006·Pharmacology & Therapeutics·Saurabh GuptaAntoinette MaassenVanDenBrink

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