Apr 1, 1996

Opposite regulation by the beta-adrenoceptor-cyclic AMP system of synaptic plasticity in the medial and lateral amygdala in vitro

Neuroscience
Y WatanabeK Abe

Abstract

The effects of beta-adrenoceptor activation on short-term potentiation in the medial and lateral amygdala were investigated using rat brain slice preparations in vitro. Application of tetanic stimulation (100 pulses at 100 Hz) induced only short-term potentiation under normal recording conditions. In the medial amygdala, when the same tetanic stimulation was applied in the presence of a beta-adrenoceptor agonist, isoproterenol, short-term potentiation was significantly enhanced and long-term potentiation was induced. Phenylephrine, an alpha-adrenoceptor agonist, did not affect short-term potentiation. The short-term potentiation-enhancing effect of isoproterenol was mimicked by forskolin, an adenylate cyclase activator, and was blocked by Rp-adenosine-3',5'-cyclic-monophosphothioate, an inhibitor of cyclic AMP-dependent protein kinase. On the other hand, in the lateral amygdala, isoproterenol suppressed short-term potentiation. The short-term potentiation-suppressing effect of isoproterenol was mimicked by forskolin, and was blocked by Rp-adenosine-3',5'-cyclic-monophosphothioate. These results suggest that the beta-adrenoceptor-cyclic AMP system plays a role in facilitating the induction of long-term potentiation in the medial...Continue Reading

Mentioned in this Paper

Phenylephrine Hydrochloride
Colforsin
Physiologic Pulse
Adenosine
Synaptic Transmission
Cyclic AMP
Adrenergic beta-Agonists
Adrenergic alpha-Agonists
Neuronal Plasticity
Cyclic Adenosine Monophosphate Measurement

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.